Journal ArticleDOI
Transplantable myeloid rat leukaemia induced by 7,12-dimethylbenz(a)anthracene.
F. Gál,S. Somfai,Z. Szentirmay +2 more
TLDR
With repeated intravenous administrations of DMBA transplantable myeloid rat leukaemia has been induced, 2 forms have developed: the subacute form maintained with and the main form, which is currently being treated with chemotherapy.Abstract:
With repeated intravenous administrations of DMBA transplantable myeloid rat leukaemia has been induced. In the course of transplantations 2 forms have developed: (1) the subacute form maintained withread more
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Journal ArticleDOI
Animal models of acute myelogenous leukaemia - development, application and future perspectives.
TL;DR: Clinicians and experimentalists are provided with a chronological, comprehensive appraisal of all AML model systems, critical discussion on the elucidation of their roles in the authors' understanding of AML and consideration to their efficacy in the development ofAML chemotherapeutics.
Journal ArticleDOI
A Critical Review of Animal Models Used in Acute Myeloid Leukemia Pathophysiology
Hala Skayneh,Batoul Jishi,Rita Hleihel,Maguy Hamieh,Nadine Darwiche,Ali Bazarbachi,Marwan El Sabban,Hiba El Hajj +7 more
TL;DR: This review provides a comprehensive and critical overview of select available AML animal models, including the non-mammalian Zebrafish and Drosophila models as well as the mammalian rodent systems, comprising rats and mice.
Journal ArticleDOI
Purification of an endopeptide to homogenity and the verification of its selective inhibitory action on myeloid cell proliferation.
TL;DR: The purification of an endogenous regulatory peptide to homogeneity which selectively inhibits the proliferation of normal and leukaemic myeloid cells is described and the structure analysis of the inhibitory endopeptide is described.
Journal Article
Primary Granulocytic Leukemia in the Rat
TL;DR: This disease presents an excellent opportunity for investigation of granulocytic proliferation and differentiation and may provide a unique test system for evaluation of chemotherapy and immunotherapy and serve as an animal model for acute granulocytetic leukemia in man.
Dissertation
Insights towards a better understanding and novel treatment modalities of Toxoplasmosis
TL;DR: P18, a Surface-Antigen 1 (SAG-1) Related Sequence (SRS) superfamily member, is characterized and a role of P18 in orchestrating the immune response, which ultimately facilitates tachyzoite trafficking to the brain and favors cyst formation is supported.