Showing papers in "The Lancet in 1977"

TL;DR: Family studies supported the view that alicyclic 4-hydroxylation of debrisoquine is controlled by a single autosomal gene and that a defect in this metabolic step is caused by a recessive allele.

TL;DR: The relationship of future clinical coronary heart-disease to the plasma-high-density-lipoprotein (H.H.D.L.)-cholesterol concentration has been examined in a 2-year case-control follow-up study of 6595 men aged 20-49 years living in the municipality of Tromsø, Norway and support the proposal that a low H.d.L. cholesterol concentration is important in accelerating the progression of coronary atherosclerosis.

TL;DR: All available colloid volume substitutes carry the risk of anaphylactoid reactions, but the frequency of severe reactions was low for plasma-protein solutions, hydroxyethyl starch, 0-008% for dextran, and 0-038% for gelatin solutions.

TL;DR: This is the first time severe psychological stress has been shown to produce a measurable abnormality in immune function which is not obviously caused by hormonal changes.

TL;DR: It is postulated that prostacyclin is important for prevention of deposition of platelets on the vessel wall and that the inhibition or prevention of the generation of prostacycliffe is important in the genesis of diseases, especially those in which increased lipid peroxidation occurs, such as atherosclerosis.

TL;DR: It is concluded that the active therapeutic moiety of S.A.S.P. is a function of the parent molecule or of these two principal metabolites of sulphapyridine and 5-aminosalicylic acid.

TL;DR: A comparison of dietary intake and faecal characteristics in population samples from two areas of Denmark and Finland with 4-fold variation in colon-cancer incidence suggests that the aetiology of colon cancer may be multifactorial and is not associated in a simple manner with dietary fat, neutral steroids, acid steroids, or their bacterial metabolites.

TL;DR: Parents who, by falsification, caused their children innumerable harmful hospital procedures--a sort of Munchausen syndrome by proxy are described.

TL;DR: A number of cases of infertility were discovered among men working in a California pesticide factory, and the suspected cause was exposure to the chemical 1,2-dibromo-3-chloropropane (D.B.C.P).

TL;DR: It is concluded that progression of the underlying pathology of the disease is probably responsible for loss of benefit in patients on chronic levodopa therapy and discovery of the exact causes may provide a rational basis for new therapy.

TL;DR: Data from five study populations participating in the Cooperative Lipoprotein Phenotyping Study indicate strong relations between reported alcohol consumption and blood-lipids and Plasma-triglycerides showed a modest positive correlation with alcohol.

TL;DR: This paper found that the removal of fibre from food, and also its physical disruption, can result in faster and easier ingestion, decreased satiety, and disturbed glucose homoeostasis which is probably due to inappropriate insulin release.

TL;DR: D.D.A.V.P. appears a promision pharmacological alternative to plasma concentrates in the management of some patients with haemophilis and von Willebrand's disease.

TL;DR: The results strongly suggest that mass-media education campaigns directed at entire communities may be very effective in reducing the risk of cardiovascular disease.

TL;DR: The results of this study indicate that screening pregnant women by measuring the concentration of A.T.F.P. in their serum is an effective method of selecting women for ultrasonography and amniocentesis so that N.D.S.s can be diagnosed in utero.

TL;DR: Indices of nutritional state were measured in surgical patients to give information on protein-calorie malnutrition, anaemia, vitamin deficiency, weight-loss, loss of arm-muscle bulk, and low plasma levels of transferrin and albumin.

TL;DR: Preliminary data for temporal lobe suggested that also in Pick's disease the density of receptor binding sites is reduced, and centrally acting anticholinesterases might be beneficial, particularly in the early stages of the disease.

TL;DR: Enkephalin-like immunoreactivity was present in all areas of the gut with particularly high concentration in the antrum and significant amounts in the upper small intestine.

TL;DR: Microsurgical tubocornual anastomosis for reversal of sterilisation has several important advantages over tubal reimplantation and may be of benefit in the treatment of infertile women with inflammatory blockage of the isthmus of the fallopian tube.

TL;DR: Fifteen patients with paracetamol (acetaminophen) poisoning were treated with intravenous N-acetylcystein (300 mg/kg given over 20 h), which was very well tolerated and has the advantage of being available as a pharmaceutical preparation in a 20% sterile solution.

TL;DR: A rigorous fefinition of coma is necessary for valid commparisons between individual patients and between different series of patients with head injury, essential for the assessment of alternative management regimens and for establishing predictive criteria.

TL;DR: Exclusion of data from the one centre did not alter already published significant differences in the total incidence of deep-vein thrombosis, nor in the frequency of operative and post-operative bleeding complications observed in the control group and the heparin group.

TL;DR: A long-term follow-up of 740 American servicemen splenectomised because of trauma during the 1939-45 war showed a significant excess mortality from pneumonia and ischaemic heart-disease, confirming that the risk of fatal infections is increased by asplenia.

TL;DR: Cerebral blood-flow was measured in patients with haematocrit values in the range 0·47-0·53 and was found to be significantly lower than in 43 patients with Hct in a lower range, which suggests Hct around the generally accepted upper limit of normal may be an important factor in the causation of occlusive vascular disease.