Open AccessJournal Article
Tumor-localizing Components of the Porphyrin Preparation Hematoporphyrin Derivative
David Kessel,Ta-Hsu Chou +1 more
TLDR
It is concluded that localization is mediated by hematoporphyrin derivative components which are among the most hydrophobic in the preparation, and apparent hydrophobicity may derive from hydrogen-bonding phenomena, rather than from absence of hydrophilic functional groups.Abstract:
Synthetic and analytical approaches were used to characterize the tumor-localizing components of the porphyrin preparation, hematoporphyrin derivative. From studies involving aqueous and nonaqueous gel exclusion and reverse-phase chromatography, we conclude that localization is mediated by hematoporphyrin derivative components which are among the most hydrophobic in the preparation. This apparent hydrophobicity may derive from hydrogen-bonding phenomena, rather than from absence of hydrophilic functional groups.read more
Citations
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Journal ArticleDOI
Photosensitizers: therapy and detection of malignant tumors
TL;DR: Perhaps the most significant advance during the past year has been the initiation of Phase III clinical trials of PDT vs standard therapy in treatment of superficial bladder cancer and obstructive endobronchial tumors.
Journal Article
Destruction of rat mammary tumor and normal tissue microcirculation by hematoporphyrin derivative photoradiation observed in vivo in sandwich observation chambers.
Willem M. Star,H. P. A. Marijnissen,A. E. Ven Den Berg-Blok,J. A. C. Versteeg,K. A. P. Franken,H. S. Reinhold +5 more
TL;DR: In the model system, tumor cell death after photoradiation occurs secondary to destruction of the microcirculation, and it is concluded that, in this system, five of five transplanted tumors did regrow.
Journal ArticleDOI
Destruction of erythroleukaemic cells by photoactivation of endogenous porphyrins
Zvi Malik,H Lugaci +1 more
TL;DR: Cells photosensitized after 5-6 days of culture were completely disintegrated leaving a nuclear remnant and an enormously swollen nuclear envelope, and the culture time dependence of the process showed an interrelationship between the photodynamic effect and porphyrin accumulation sites in cellular compartments.
Journal ArticleDOI
HEMATOPORPHYRIN and HPD: PHOTOPHYSICS, PHOTOCHEMISTRY and PHOTOTHERAPY
TL;DR: The topic of porphyrin photosensitization was reviewed in this Journal three years ago as part of a commentary on photodynamic dye action and a substantial amount of new literature has appeared during the intervening years.
Book ChapterDOI
The structure of the active component of hematoporphyrin derivative.
TL;DR: Photoradiation therapy for local treatment of malignant tumors utilizing hematoporphyrin derivative as photosensitizing drug is undergoing clinical trials in several centers in the U. S. and abroad.
References
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Journal Article
Photoradiation therapy for the treatment of malignant tumors
Thomas J. Dougherty,Jerome E. Kaufman,Abraham Goldfarb,Kenneth R. Weishaupt,Donn Boyle,Arnold Mittleman +5 more
TL;DR: Deep-seated and pigmented tumors required a higher dose of drug for effective treatment than did the more superficial and nonpigmented lesions, and a high therapeutic ratio between tumor and skin response has been obtained.
Journal ArticleDOI
The use of a derivative of hematoporphyrin in tumor detection.
Journal Article
Determination of [3h]- and [14c]hematoporphyrin derivative distribution in malignant and normal tissue.
TL;DR: The results tend to disprove the generalization that HPD accumulates in malignant tissue to a higher degree than in all normal tissue and it is reported that gross visualization of porphyrin fluorescence cannot be correlated with actual tissue concentrations of the dye.
Journal ArticleDOI
Photoradiation in the Treatment of Recurrent Breast Carcinoma
Thomas J. Dougherty,Gilbert Lawrence,Jerome H. Kaufman,Donn Boyle,Kenneth R. Weishaupt,Abraham Goldfarb +5 more
TL;DR: Photoradiation, with the use of hematoporphyrin derivative activated by visible light in the red region of the spectrum, was an effective treatment for controlling local and regional chest wall recurrences of breast carcinoma.
Journal ArticleDOI
The mechanism of photodynamic inactivation of human cells in vitro in the presence of haematoporphyrin
TL;DR: Two findings indicate that the photoinduced damage is repairable: firstly, the fraction of cells surviving a given light dose decreases with decreasing irradiation temperature, and secondly, the survival curves have a shoulder at low exposures of light.