Open AccessJournal Article
Ultrastructure autoradiography and lysosome studies in myocardium.
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This article is published in Journal of the Mount Sinai Hospital, New York.The article was published on 1965-03-01 and is currently open access. It has received 18 citations till now. The article focuses on the topics: Lysosome.read more
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Reduction of Experimental Myocardial Infarct Size by Corticosteroid Administration
TL;DR: Pharmacological doses of hydrocortisone prevent myocardial cells from progressing to ischemic necrosis even when administration is initiated 6 h after coronary occlusion, showing that over one third of the sites were protected from undergoing necrosis due to the intervening hydroc Cortisone treatment.
Journal ArticleDOI
On the nature of cell death during remodeling of hypertrophied human myocardium.
TL;DR: A chronic self-controlled cytoplasmic proteolysis in cardiocytes is postulate, not initially associated with either nuclear degradation or intercellular dehiscence but later possibly accompanied by apoptotic nuclear elimination, and leading to apoptotic cell death.
Journal ArticleDOI
Myocardial lysosome stability in the early stages of acute ischemic injury
TL;DR: The presence of lysosome involvement in hypoxic sites that lost glycogen but not potassium indicates that the intracellular release of acid hydrolases occurs before cellular death and may contribute to the initiation of the process of cellular injury.
Journal ArticleDOI
Lysosomes and myocardial cellular injury
TL;DR: The extent of the lysosome involvement and the relatively small degree of necrosis present in the papillary muscle sites by 60 minutes, when coupled with the well known hydrolytic capacity of lysOSome acid hydrolysis, suggests that the intracellular release of lYSosomal enzymes precedes cellular death and may initiate the cellular injury process.