scispace - formally typeset
Search or ask a question

2023 What are the latest developments in platelet research? 


Best insight from top research papers

Recent developments in platelet research have revealed the significant role played by platelets in various pathologies and regenerative processes, opening up exciting opportunities for clinical applications in fields such as regenerative medicine and cancer treatment . Platelet heterogeneity has been recognized, with differences in biochemistry and function observed among platelet subpopulations . Proteomic techniques have advanced our understanding of platelet biology, providing insights into physiological pathways and identifying potential biomarkers for diagnosis and drug targets . Platelets have also been used as easily accessible cells to study neurological disorders, offering insights into the underlying pathophysiological mechanisms . Microfluidic technology has advanced the analysis of platelet aggregation and thrombosis kinetics, providing a versatile platform for basic research and clinical diagnostic applications . These recent developments in platelet research have expanded our knowledge of platelet functions and their implications in various diseases, paving the way for future advancements in diagnosis, treatment, and therapeutic interventions.

Answers from top 3 papers

More filters
Papers (3)Insight
The recent advances in platelet proteomics have allowed a better understanding of platelet biology and the discovery of potential biomarkers for diagnosis and drug targets.
The text does not provide information about the latest developments in platelet research.
Open accessJournal ArticleDOI
Gabriela Lesyk, Paul Jurasz 
25 Citations
The text does not provide information about the latest developments in platelet research.

See what other people are reading

What is the nature of the target means function of the protein during drug discovery or development?
5 answers
Proteins play a crucial role in drug discovery and development as they serve as potential drug targets. Protein-protein interactions are also highlighted as promising targets for drug discovery, although challenges exist in developing small molecule drugs that can effectively bind to these interaction surfaces. Target proteins and genes are essential for developing novel physiologically active substances like drugs, with methods for screening substances and regulating physiological activities being key components in this process. Target-based drug discovery typically involves identifying and validating proteins as drug targets, followed by lead compound screening through various methods like high throughput screening or fragment-based drug discovery. Computational approaches are utilized to investigate protein drug targets, with a focus on identifying properties of proteins that make them suitable for pharmaceutical modulation, such as sequence-related features and hydrophobicities.
How silver nanoparticle use for fracture?
5 answers
Silver nanoparticles (AgNPs) have shown promising applications in fracture healing. Studies have highlighted the potential of AgNPs in promoting bone regeneration. AgNPs have been incorporated into materials like gelatin hydrogels, enhancing osteoblast cell survival and spreading, thus aiding in bone fracture healing. Additionally, AgNPs have been utilized in combination with vascular endothelial growth factor (VEGF) to improve wound healing and reduce aseptic necrosis in femoral fracture treatment, showing enhanced cell adhesion and proliferation of mesenchymal stem cells. Furthermore, the use of AgNPs in nanocomposites with thermoplastic polyurethane has demonstrated effectiveness in inhibiting bacterial growth, reducing inflammation, and improving functional rehabilitation in diabetic patients with open fractures of lower extremities. These findings collectively suggest the potential of AgNPs in enhancing fracture healing processes.
How silver nanoparticle use for fracture healing?
5 answers
Silver nanoparticles (AgNPs) have shown significant potential in fracture healing due to their antimicrobial properties and ability to promote bone regeneration. Studies have highlighted the effectiveness of AgNPs in improving fracture healing by providing fine structures for bone tissue engineering. Incorporating AgNPs in materials like thermoplastic polyurethane (TPU) has been found to inhibit bacterial growth, reduce inflammation, and enhance wound healing in diabetic patients with open fractures. Additionally, AgNPs incorporated in hydrogels have demonstrated excellent antimicrobial activity and accelerated wound recovery, making them promising for treating surgical excision wounds and promoting burn wound healing. Gelatin-stabilized AgNPs have been shown to be non-toxic to osteoblasts and capable of modulating bone fracture healing, indicating their potential in nursing care for bone injuries. Overall, AgNPs present a versatile and effective approach for enhancing fracture healing processes.
How to numerically simulate electrolysis around catheter in blood?
5 answers
To numerically simulate electrolysis around a catheter in blood, one can utilize computational models that consider various factors. Models integrating blood dynamics with the Navier-Stokes equations and substance dispersion through advection diffusion equations can simulate the physical processes during catheter injection. Additionally, incorporating a dynamic computational fluid program can help simulate blood flow within central venous catheters, assessing factors like shear stress, velocity, and pressure, especially when catheters are obstructed. Furthermore, adapting finite element modeling programs can provide accurate solutions for laminar blood flow around intra-arterial catheters, aiding in predicting thrombus activation sites and deposition through analysis of velocity, pressure fields, shear rates, and particle paths. These approaches can collectively contribute to a comprehensive numerical simulation of electrolysis around catheters in blood, considering both fluid dynamics and catheter design aspects.
What is the specific molecular target of chloroquine in Haemonchus contortus that leads to the inhibition of toxicity?
5 answers
Chloroquine (CQ) inhibits the activity of CYP2D6, an essential enzyme for primaquine (PQ) pharmacologic activity in Haemonchus contortus. This inhibition affects the metabolism of PQ, shifting metabolite pathway balances to reduce toxicity while maintaining efficacy against the parasite. Additionally, CQ suppresses CYP2D6-mediated hydroxylation and the formation of certain metabolites, such as glucuronides, in a dose-dependent manner. The complex interactions between CQ and PQ metabolism suggest a mechanism where CQ alters metabolite pathways to retain efficacy and reduce toxic metabolites, potentially by affecting transport or distribution of metabolites in a way that mitigates toxicity while preserving anti-malarial activity.
Ticagrelor inhibitory effect on activation of STAT3 signaling pathway?
5 answers
Ticagrelor has been extensively studied for its pharmacological effects beyond platelet inhibition. While it inhibits various pathways like NLRP3 inflammasome activation, GSK-3β/caspase-1/GSDMD activation, and platelet-neutrophil interactions leading to NET formation, there is no direct evidence in the provided contexts regarding its inhibitory effect on the STAT3 signaling pathway. The research primarily focuses on ticagrelor's impact on inflammation, pyroptosis, and platelet-related processes. Therefore, based on the available data, there is no indication that ticagrelor directly inhibits the activation of the STAT3 signaling pathway.
Ticagrelor inhibitory effect on activation of NF-kB signaling pathway?
5 answers
Ticagrelor exhibits inhibitory effects on the activation of the NF-κB signaling pathway. It prevents the degradation of IKBα, phosphorylation of p65, and the translocation of p65 into the nucleus, thereby reducing the production of inflammatory factors like TNFα, IL-1, IL-8, IL-6, and IL-2. Ticagrelor also downregulates NF-κB and galectin-3 expressions, along with IL-6 and TNF-α levels, in ischemic conditions. Moreover, ticagrelor inhibits the NLRP3 inflammasome activation independent of its classic P2Y12 inhibitory effect, showing promise in mitigating systemic inflammation. These findings collectively suggest that ticagrelor's modulation of the NF-κB pathway contributes to its anti-inflammatory properties, highlighting its potential therapeutic role in conditions involving NF-κB-mediated inflammation.
What is the controversial effect of streptococcus mutans on health and dental plaque?
4 answers
Streptococcus mutans (S. mutans) has a controversial role in oral health and dental plaque formation. Research indicates that S. mutans dexA gene deletion alters biofilm structure and microbiota composition, potentially reducing cariogenicity. Conversely, S. mutans abundance is associated with oral squamous cell carcinoma (OSCC) development and progression, suggesting a detrimental impact on oral health. Furthermore, the absence of S. mutans in some cases of severe early childhood caries (SECC) highlights a potential protective effect against caries, with other bacteria like Leptotrichia, Selenomonas, and Prevotella_7 identified as biomarkers in S. mutans-low SECC cases. Additionally, the rhamnose-glucose polysaccharide (RGP) of S. mutans plays a crucial role in biofilm formation and stress response, with implications for oxidative stress tolerance and iron uptake.
When is gel fraction high?
5 answers
The gel fraction is high when a polymer dispersion composition contains a gel content of 50% or more. Additionally, in the formation of a gel emulsion with a high internal oil phase volume fraction, the resulting gel emulsion exhibited excellent stability, containing a small fraction of liquid crystal according to the phase diagram. These instances highlight conditions where gel fractions are notably high, indicating a significant presence of gel-like structures within the respective systems. Therefore, the gel fraction is high in scenarios involving polymer dispersion compositions with a gel content exceeding 50% and in stable gel emulsions with a substantial internal oil phase volume fraction.
What is the role of neutrophil-monocyte aggregates?
5 answers
Neutrophil-monocyte aggregates play a crucial role in various pathological conditions. These aggregates are influenced by inflammation and can contribute to exacerbating inflammatory responses in diseases like atherosclerosis and lupus. In atherosclerosis, monocyte-platelet aggregates are associated with disease progression, especially during acute events like myocardial infarction. In autoimmune diseases like lupus, neutrophils interact with immune complexes, leading to the activation of immune cells and tissue damage. Furthermore, neutrophils in Papillon-Lefevre syndrome lack the ability to form neutrophil extracellular traps (NETs) and associated aggregates, which results in nonresolving periodontitis due to the absence of a negative feedback mechanism for inflammation. Overall, neutrophil-monocyte aggregates are pivotal in linking inflammatory and immune responses in various diseases.
Can S. cerevisiae be used as a model organism to study various stresses in eukaryotic cells?
5 answers
Yes, S. cerevisiae can indeed be utilized as a model organism to study various stresses in eukaryotic cells. The yeast's ability to sense and respond to nutrient availability, as well as its response to stressors like caffeine, hydroxyurea, and hydrogen peroxide, makes it a valuable system for stress response research. Prolonged cell cycle arrests in yeast lead to growth attenuation and activation of stress-induced signaling pathways, similar to responses observed in human cell lines, indicating conservation in stress responses. Additionally, S. cerevisiae has been instrumental in elucidating highly conserved biological processes like the DNA damage response pathway, showcasing its utility in stress-related studies. Furthermore, the identification of stress-responsive small open reading frame-encoded peptides in yeast under various stress conditions highlights its potential for understanding cellular stress responses at a molecular level.