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Alteration in cocaine addcition pathway could affects the body's ability to combat cancer?

Chromatin immunoprecipitation

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Alterations in metabolic pathways, such as purine metabolism, can impact cancer progression. Research on DDX3 alteration in HPV-associated lung cancers revealed that changes in the p53-DDX3 pathway can enhance tumor progression by affecting p21 expression, leading to poor relapse-free survival in lung cancer patients. These findings suggest that disruptions in specific pathways, like the p53-DDX3-p21 axis, can indeed influence cancer development and outcomes. While the direct impact of cocaine addiction pathway alterations on cancer combat is not explicitly studied in the provided contexts, the intricate interplay between metabolic pathways and cancer progression underscores the potential for broader systemic effects on the body's ability to combat cancer when essential pathways are dysregulated.

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Posted Content•DOI Data from Reduced p21<sup>WAF1/CIP1</sup> via Alteration of p53-DDX3 Pathway Is Associated with Poor Relapse-Free Survival in Early-Stage Human Papillomavirus–Associated Lung Cancer 31 Mar 2023	Not addressed in the paper.
Posted Content•DOI Data from Reduced p21<sup>WAF1/CIP1</sup> via Alteration of p53-DDX3 Pathway Is Associated with Poor Relapse-Free Survival in Early-Stage Human Papillomavirus–Associated Lung Cancer 31 Mar 2023	Not addressed in the paper.
Posted Content•DOI Supplementary Data from Reduced p21<sup>WAF1/CIP1</sup> via Alteration of p53-DDX3 Pathway Is Associated with Poor Relapse-Free Survival in Early-Stage Human Papillomavirus–Associated Lung Cancer 31 Mar 2023	Not addressed in the paper.
Posted Content•DOI Supplementary Data from Reduced p21<sup>WAF1/CIP1</sup> via Alteration of p53-DDX3 Pathway Is Associated with Poor Relapse-Free Survival in Early-Stage Human Papillomavirus–Associated Lung Cancer 31 Mar 2023	Not addressed in the paper.

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