scispace - formally typeset
Search or ask a question

Amperometric investigation of nickel and cobalt complexes with cephalexin 

Molecule
Metal ions in aqueous solution
Nickel
Cobalt
Carboxylate
Best insight from top research papers

Amperometric investigations of nickel and cobalt complexes with cephalexin have been conducted in various studies. The complexes formed under specific experimental conditions have been characterized, showing the formation of [NiCEF]+ and [CoCEF]+ complexes with stability constants log K′ = 3.16 for Ni(II)-cephalexin and log K′ = 3.09 for Co(II)-cephalexin . Additionally, the protonation constants of the anion of ceftazidime and the formation constants of its complexes with Ni2+ have been determined, with logβ(NiCtzd)+ = 4.04 ± 0.03 . Furthermore, the synthesis, characterization, and biological evaluation of new Co II and Ni II complexes of cefodroxil have been studied, showing enhanced antibacterial activity compared to the parent antibiotic . These studies provide valuable insights into the electrochemical behavior and potential applications of nickel and cobalt complexes with cephalosporin antibiotics.

Answers from top 5 papers

More filters
Papers (5)Insight
Open access•Journal Article•DOI
Synthesis, Characterization, Biological Activity and Voltammetric Behavior and Determination of Cefaclor Metal Complexes
Derya Tarinc, Burcu Dogan-Topal, Mustafa Dolaz, Ayşegül Gölcü, Sibel A. Ozkan 
30 Sep 2010-Current Analytical Chemistry
12 Citations
Not addressed in the paper.
Journal Article•DOI
Synthesis and antibacterial activity of cephalexin metal complexes
Juan R. Anacona, Ibranyellis Rodriguez 
15 Oct 2004-Journal of Coordination Chemistry
63 Citations
Not addressed in the paper.
Journal Article•DOI
Amperometric investigation of nickel and cobalt complexes with cephalexin
Vera Kapetanović, Desanka Ž. Sužnjević, Dragan S. Veselinović 
01 Aug 1990-Electroanalysis
7 Citations
Nickel and cobalt complexes with cephalexin were studied amperometrically, forming [NiCEF]+ and [CoCEF]+ complexes with stability constants log K′ = 3.16 and 3.09, respectively.
Journal Article•DOI
Experimental study and computer modeling of Ni(II) and Cu(II) complexation with ceftazidime
V. G. Alekseev, E. M. Sokolova 
13 May 2016-Russian Journal of Inorganic Chemistry
2 Citations
Not addressed in the paper.
Open access
Synthesis, Characterization and Antimicrobial studies of Transition metal complexes of Co(II) and Ni(II) derived from Cefadroxil
Kanti Pachori, Suman Malik, Sonal Wankhede, Singh Patel 
01 Jan 2014
3 Citations
Not addressed in the paper.

Related Questions

How soon sh;ould i receive results from a ;wound injury with cephalixin?5 answersAfter sustaining a wound injury and receiving treatment with cephalexin, the timeframe for observing results may vary based on the severity of the infection and individual response to the antibiotic. Studies have shown that cephalexin is effective in treating postoperative wound infections, lower respiratory tract infections, and soft tissue infections caused by Staphylococcus aureus. In cases of secondarily infected wounds, clinical success rates with cephalexin were comparable to topical mupirocin, with a high rate of bacteriologic success as well. Additionally, in the context of uncomplicated skin and soft tissue abscesses, cephalexin showed a clinical cure rate of 84.1% after incision and drainage, indicating its efficacy against community strains of MRSA. Therefore, while individual response times may vary, cephalexin has demonstrated effectiveness in treating various types of infections, with results typically observed within a few days to a week.
How does the spectrophotometric analysis of Cephalexin complex aid in determining the purity and potency of the drug?5 answersThe spectrophotometric analysis of Cephalexin complex plays a crucial role in determining the purity and potency of the drug. Various methods have been developed for this purpose, such as the oxidation-based method using N-Bromosuccinimide and Evans blue dye for Cephalexin monohydrate, Ceftriaxone sodium, and Cefotaxim sodium. Additionally, the coupling reaction between diazotized Cefotaxime and 3,5-dimethyl phenol in basic medium provides a sensitive method for Cefotaxime determination in pure and pharmaceutical samples. These methods offer accurate quantification over specific concentration ranges, with high molar absorptivities and low limits of detection, ensuring the reliability of the analysis for assessing the purity and potency of Cephalexin and related drugs in various formulations.
Electrodeposition of nickel ?5 answersThe electrodeposition of nickel has been studied in various contexts. In one study, nickel-copper (Ni-Cu) alloy films were electrodeposited on copper substrates from aqueous solutions with organic additives. Another study investigated the electrodeposition of nickel films from two different solvents, aqueous acetate buffer and ethaline solvent, for use as electrocatalysts. Composite electrodeposition of nickel matrix coatings with borides ceramic particles has also been explored. Additionally, the electrodeposition of nickel-iron-based coatings on stainless-steel substrates for water electrolysis applications has been investigated. Finally, the electrodeposition of nickel in 1-butyl-3-methylimidazolium diethylphosphate ionic liquid without any additives has been studied.
Amperometry is an electrochemical method5 answersAmperometry is an electrochemical method used for various applications such as quantifying compounds, detecting neurotransmitters, and evaluating the antioxidant capacity of beers. It involves the measurement of electric current generated by redox reactions at an electrode surface. The technique has been used to evaluate the catalytic activity of nitroxyl radicals and their ability to sense biological and other compounds. Intermittent pulse amperometry (IPA) has been proposed as an alternative method for the analysis of 4-nitrophenol (4-NP), offering simplicity and high performance. Amperometry is also used for the detection of neurotransmitters released from and stored inside cells, providing sub-millisecond temporal resolution and generating large amounts of high-quality data. Additionally, amperometry can be used for the analysis of exocytosis processes in real-time, with the frequency domain analysis using Fast Fourier Transform (FFT) providing statistical validation of observations on spike characteristics. Microdialysis online-coupled with amperometry has been shown to be suitable for the evaluation of the antioxidant capacity of beers, allowing for assay automation and effective removal of electrode fouling.
How can nickel chelate chromatography be improved?2 answersNickel chelate chromatography can be improved by using a resin containing nickel ions (Ni2+) that have been immobilized by covalently attached nitrilotriacetic acid (NTA). This technique, known as metal-chelate affinity chromatography (MCAC), allows for the purification of recombinant proteins engineered with six consecutive histidine residues on either the amino or carboxyl terminus. The use of MCAC can be performed with either native or denatured proteins, and the purification process can be adapted to any protein expression system. Additionally, the immobilization of six histidine-containing proteins onto microtiter plates using a derivative of NTA coupled to a polystyrene plate charged with Ni2+ has been shown to specifically capture proteins with the 6His tag. This technology can be used for protein quantitation, determining protein-ligand interactions, and high-throughput screening assays for protein-protein interactions.
Can you donate plasma while taking cephalexin?6 answers

See what other people are reading

How the nails market is going?
5 answers
The nail market is experiencing various trends and developments across different regions. In Brazil, the nail polish market is expanding rapidly, with a focus on customer loyalty strategies to drive profitability and market growth. In Colombia, a company named Masglo is prominent in selling nail polish, although some of its marketing strategies have faced criticism for associating nail polish colors with negative connotations. On the other hand, in Kurdistan Region of Iraq, the cosmetic market, including nail products, is flourishing due to the increasing use of cosmetics and the influence of social media on consumer behavior. Additionally, advancements in nail treatment options, such as the development of safer topical treatments like efinaconazole and tavaborole, are underway to address issues like onychomycosis effectively.Is there data available where carbon capturing was measured using Metal-Organic Framework with Carbonic Anhydrase and without?
5 answers
The efficiency of carbon capturing using Metal-Organic Frameworks (MOFs) with and without Carbonic Anhydrase (CA) has been evaluated. MOFs are known for their high CO2 adsorption capacity, while CA enzymes accelerate CO2 hydration. Studies have shown that MOFs can be tuned for improved CO2 uptake, and hybridization with other materials can enhance their properties for CO2 capture applications. Additionally, neural network potentials based on density-functional theory have been developed to predict the thermal properties of amine-appended MOFs, aiding in understanding their carbon capture dynamics. Therefore, data is available on the synergistic effects of combining MOFs with CA enzymes for efficient carbon capturing, shedding light on the potential of this hybrid approach for enhanced CO2 sequestration.Why dichloromethane polarity is low?
5 answers
Dichloromethane exhibits low polarity due to its nature as a low-polarity solvent, as evidenced by the establishment of a basicity scale for weak bases in 1,2-dichloroethane. Additionally, the rectification process involving the addition of ethylene glycol aids in separating and purifying the moisture content of dichloromethane, contributing to its low polarity characteristics. Furthermore, studies on nickel phthalocyaninates in dichloromethane solutions have shown the existence of associated forms even at very low concentrations, indicating the solvent's low polarity properties. Molecular dynamics simulations on organic liquids like methylchloromethane have highlighted that the inclusion of polarization in the solvent does not significantly impact its structure but slightly slows down dynamics, emphasizing the low polarity nature of dichloromethane.What is the interaction between cox-2 and lox heme iron?
5 answers
The interaction between COX-2 and LOX heme iron involves various aspects. COX-2, a key enzyme in inflammation, interacts with heme iron, affecting its function. On the other hand, LOX, involved in lipid metabolism, interacts with heme iron in a different manner. Studies have shown that heme iron of myoglobin directly interacts with additional metal ions like Cu(II), Zn(II), and Co(II), leading to the displacement of iron ions from the heme prosthetic group. Additionally, heme oxygenases (HO-1 and HO-2) catalyze the conversion of heme to carbon monoxide, iron, and biliverdin, impacting vasorelaxation. These interactions highlight the significance of heme iron in various biological processes and the diverse roles it plays in enzyme activities and physiological functions.How does the size of cavity impact affinity of crown ethers, specifically benzo crown ethers?
5 answers
The size of the cavity in crown ethers, particularly benzo crown ethers, significantly influences their affinity for ions. Research shows that as the cavity size increases, the corrosion inhibition efficiency of crown ethers also increases, with dibenzo-24-crown-8 exhibiting the highest efficiency. Additionally, the size matching between the cavity of the crown ethers and metal ions plays a crucial role in the formation of conformers, with larger ions leading to deformation of the ether ring to optimize interactions. Moreover, embedding crown ethers in a graphane lattice can enhance the binding strength for alkali metal cations by up to 14 times, offering potential applications in alkali metal cation separation. The combination of cavity size and structural modifications in crown ethers influences their affinity for ions, showcasing the importance of cavity size in determining their properties.Does moral grammar model or dual process theory better captures moral mind?
5 answers
The debate between the Moral Grammar Model and Dual Process Theory revolves around how moral cognition is best understood. Dual Process Theory, as discussed in, posits two types of cognitive processes - heuristic and analytic - influencing moral judgments. However, recent research, as highlighted inand, advocates for a shift towards dynamic system models of moral cognition. This perspective emphasizes the automatic elicitation of moral intuitions followed by reasoning to correct initial judgments, showcasing the diverse and distributed nature of moral computations in the brain. Additionally, the limitations of simplistic automatic/controlled distinctions in implicit moral cognition are addressed in, suggesting that moral reasoning can play a more significant role than previously thought. Therefore, the dynamic system models proposed in recent research seem to better capture the complexities of the moral mind compared to the traditional Dual Process Theory.When is gel fraction high 90%?
5 answers
The gel fraction is considered high when it reaches 90% or more. In the context of encapsulation materials for photovoltaic modules, a gel content between 65% to 90% is crucial to ensure proper lamination and long-term durability. Similarly, in the entrapment of flavors and fragrances, a copolymer hydrogel can entrap these substances in amounts up to 90% of the total formulation. Achieving such high gel fractions is essential for the functionality and performance of various materials, whether in photovoltaic applications or fragrance encapsulation. Therefore, maintaining a gel fraction of 90% or higher is a significant parameter in ensuring the effectiveness and quality of the materials being utilized.How does the preparation of fragrance microemulsions differ from traditional methods of fragrance formulation?
5 answers
The preparation of fragrance microemulsions differs from traditional methods of fragrance formulation by involving the creation of nanostructures within the system. These nanostructures are formed by mixing water, water surfactant, fragrance material, and fragrance surfactant, followed by high-energy homogenization techniques like microfluidization and sonication. In contrast, traditional methods focus on the phase behavior of perfume raw materials within surfactant-based formulations, influenced by factors like structure and hydrophobicity of the raw materials. The addition of water in rinse-off products further affects the phase behavior, leading to the identification of specific compositions in micellar, microemulsion, and transition regions through phase diagrams and structural analyses using techniques like small-angle neutron scattering (SANS).How does the arrangement of atoms in a crystalline structure affect the number of coordination bonds?
5 answers
The arrangement of atoms in a crystalline structure significantly influences the number of coordination bonds formed. The coordination number, which represents the number of atoms or ions surrounding a central atom in a crystal lattice, is impacted by factors such as atomic radii, electronegativity, and packing arrangements. The coordination number parity law highlights that polyhedra with an odd number of vertices occur less frequently, with distortions affecting bond lengths and symmetry. Additionally, the coordination number tends to decrease with increasing central cation coordination number due to variations in Born repulsion and Coulomb attraction. Nanocrystals exhibit a lowered average coordination number compared to infinite lattices, emphasizing the influence of crystal size on coordination bonds.What types of antibacterial peptides have been conjugated with curcumin?
5 answers
Antibacterial peptides such as cell-penetrating peptide-octaarginine (R8) have been conjugated with curcumin to enhance antibacterial activity. Additionally, novel conjugates of cobalt bis(dicarbollide) and closo-dodecaborate with curcumin have been synthesized, showing activity against Gram-positive microorganisms like Staphylococcus aureus and Enterococcus faecalis. Furthermore, mixed bioconjugates of curcumin containing biodegradable bonds have been prepared and tested for antibacterial activity, demonstrating significant enhancement compared to curcumin alone. These studies highlight the potential of conjugating curcumin with various antibacterial peptides to improve its efficacy against a range of bacterial strains.Is self-awareness self-recognition?
5 answers
Self-awareness and self-recognition are interconnected but distinct concepts. Self-recognition, such as mirror self-recognition (MSR), is often considered a benchmark of objective self-awareness, indicating the ability to think about oneself. However, self-awareness encompasses more than just recognizing oneself in a mirror. For instance, private self-awareness involves introspection and access to internal states beyond mere visual recognition. Studies on guidance and counseling students also highlight different aspects of self-awareness, including attention, wakefulness, architecture, recall of knowledge, and emotive aspects, indicating a multifaceted understanding of self-awareness. Therefore, while self-recognition can be a component of self-awareness, the latter involves a broader and deeper understanding of oneself beyond visual identification.