Are there changes of gene expression related to mechanotransduction and stress response under s-µG condition?
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Changes in gene expression related to mechanotransduction and stress response have been observed under simulated microgravity (s-µG) conditions. Studies have shown that microgravity affects genes involved in circadian clocks, mechanotransduction pathways, immune response, metabolism, and cell proliferation . Additionally, the response to mechanical stress in living organisms includes upregulation of genes involved in stress response, cuticle development, and signaling pathways such as WNT, TGFβ, AMPK, and Hedgehog signaling . Furthermore, the nuclear architecture and cytoskeleton play a role in mechanotransduction, with alterations in nuclear stiffness and nuclear remodeling influencing gene expression and cell fate . Actin remodeling, regulated by the Rho/Rho-kinase signaling pathway, has been shown to control gene expression in response to mechanical stimuli . These findings suggest that changes in gene expression related to mechanotransduction and stress response occur under s-µG conditions, highlighting the importance of understanding the molecular mechanisms involved in adapting to altered gravitational forces.
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47 Citations | The paper mentions that microgravity affects genes that regulate circadian clocks, activate mechanotransduction pathways, and induce changes in immune response, metabolism, and cell proliferation. Therefore, there are changes in gene expression related to mechanotransduction under microgravity conditions. However, the paper does not specifically mention changes in gene expression related to stress response under microgravity conditions. |
| The provided paper does not specifically mention changes in gene expression related to mechanotransduction and stress response under s-µG (simulated microgravity) conditions. | |
| The provided paper does not mention changes in gene expression related to mechanotransduction and stress response under s-µG (simulated microgravity) conditions. | |
3 Citations | The provided paper does not mention anything about changes in gene expression related to mechanotransduction and stress response under s-µG (simulated microgravity) conditions. |
6 Citations | The provided paper does not discuss changes in gene expression related to mechanotransduction and stress response under s-µG (microgravity) conditions. |
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