F
Farshid Guilak
Researcher at Washington University in St. Louis
Publications - 499
Citations - 46253
Farshid Guilak is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Cartilage & Osteoarthritis. The author has an hindex of 110, co-authored 480 publications receiving 41327 citations. Previous affiliations of Farshid Guilak include University of Washington & AO Foundation.
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Journal ArticleDOI
Control of stem cell fate by physical interactions with the extracellular matrix.
Farshid Guilak,Daniel M. Cohen,Bradley T. Estes,Jeffrey M. Gimble,Wolfgang Liedtke,Christopher S. Chen +5 more
TL;DR: Some of the physical processes by which cues from the ECM can influence stem cell fate are reviewed, with particular relevance to the use of stem cells in tissue engineering and regenerative medicine.
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RNA-guided gene activation by CRISPR-Cas9-based transcription factors
Pablo Perez-Pinera,D. Dewran Kocak,Christopher M. Vockley,Andrew F. Adler,Ami M. Kabadi,Lauren R. Polstein,Pratiksha I. Thakore,Katherine A. Glass,David G. Ousterout,Kam W. Leong,Kam W. Leong,Farshid Guilak,Gregory E. Crawford,Timothy E. Reddy,Charles A. Gersbach +14 more
TL;DR: A Cas9-based transactivator that is targeted to DNA sequences by guide RNA molecules is created, demonstrating a simple and versatile approach for RNA-guided gene activation.
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Adipose-derived adult stem cells: isolation, characterization, and differentiation potential
Jeffrey M. Gimble,Farshid Guilak +1 more
TL;DR: Adipose tissue is an abundant, accessible, and replenishable source of adult stem cells that can be isolated from liposuction waste tissue by collagenase digestion and differential centrifugation, and these ADAS cells have potential applications for the repair and regeneration of acute and chronically damaged tissues.
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3D Printing of Highly Stretchable and Tough Hydrogels into Complex, Cellularized Structures
Sungmin Hong,Dalton G. Sycks,Hon Fai Chan,Shaoting Lin,Shaoting Lin,Gabriel P. López,Farshid Guilak,Kam W. Leong,Kam W. Leong,Xuanhe Zhao,Xuanhe Zhao +10 more
TL;DR: A 3D printable and highly stretchable tough hydrogel is developed by combining poly(ethylene glycol) and sodium alginate, which synergize to form a hydrogels tougher than natural cartilage.
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Chondrogenic differentiation of adipose-derived adult stem cells in agarose, alginate, and gelatin scaffolds.
TL;DR: The findings of this study suggest that various biomaterials support the chondrogenic differentiation of hADAS cells, and that manipulating the composition of these tissue engineered constructs may have significant effects on their mechanical properties.