Can Candida albicans cause pelvic inflammatory disease?
Answers from top 10 papers
More filters
| Papers (10) | Insight |
|---|---|
Open access•Journal Article 83 Citations | In patients with RVVC caused by Candida albicans, host factors may play an important role. |
| Candida albicans, an opportunistic fungal pathogen, colonizes 20% of women without causing any overt symptoms, yet it is one of the leading causes of infectious vaginitis. | |
86 Citations | Although some studies show rapid changes in the uropathogenesis of Candida species causing urinary tract infections in some countries, Candida albicans is still the most important cause of candidal urinary tract infections. |
119 Citations | Candida albicans may also play a role in the persistence or worsening of some chronic inflammatory bowel diseases. |
| albicans, but not non-albicans Candida, was associated with atrophic glossitis in xerostomia patients who had no systemic predisposing factors, indicating that C. albicans remains a treatment target for Candida-related atrophic glossitis. | |
| Therefore, it can be concluded that non-albicans Candida species have emerged as an important cause of infections. | |
| Women with recurrent C. albicans vaginitis appear to produce Candida-specific suppressor lymphocytes which block the cellular immune response to this organism. | |
| The statistical analyses confirmed the significant association between Urinary Tract Infections caused by Candida albicans and female gender (P<0.05). | |
Open access•Journal Article 42 Citations | This is the only case to our knowledge of Candida albicans arthritis and osteomyelitis occurring either in a patient infected with human immunodeficiency virus or in the sternoclavicular joint. |
85 Citations | albicans challenge constitute good evidence for induction of locally expressed Candida-specific Ab and cellular responses which are potentially involved in anticandidal protection at the vaginal level. |
Related Questions
Candida pelvic infections in humans?5 answersCandida pelvic infections can occur in humans, with different forms of genitourinary candidiasis affecting different populations. Vulvovaginal candidiasis primarily affects healthy women, while candiduria is more common in elderly, hospitalized, immunocompromised patients, and neonates. The incidence and prevalence of vulvovaginal candidiasis vary across different countries, including the United States, Mexico, and various Latin American countries. Antifungal resistance, particularly to voriconazole, is a concern in the treatment of Candida infections, although there is no significant association between antifungal sensitivity and virulence markers of Candida species. Despite the high clinical relevance of genitourinary candidiasis, there is still a need for further research to better understand its pathogenesis and establish treatment guidelines.
What is known about pelvic inflammatory disease?5 answersPelvic inflammatory disease (PID) is a clinical syndrome associated with various potential causal pathogens. These include sexually transmitted organisms such as Neisseria gonorrhoeae and Chlamydia trachomatis, bacterial vaginosis-associated species and genera, and genera and species usually associated with the gastrointestinal or respiratory tracts. However, gonorrhea or chlamydia is found in only a fraction of PID cases, suggesting the need for broader screening and diagnostic strategies. The incidence of PID may be decreasing, but the etiologic cause and rate of decrease vary. Mycoplasma genitalium, respiratory pathogens, and bacteria associated with bacterial vaginosis may account for a significant proportion of PID cases. PID can present acutely with lower abdominal or pelvic pain, but many cases are subtle or asymptomatic, leading to delayed diagnosis and complications such as infertility or chronic pelvic pain. Treatment of PID has slowly evolved, considering the polymicrobial nature of the disease and the emergence of novel organisms like Mycoplasma genitalium. Point of care testing and alternative approaches are crucial for improving PID diagnosis and management.
What are the causes of vaginal candidiasis?4 answersVaginal candidiasis is caused by yeast of the genus Candida. Candida albicans is the most common cause, but there is an increasing involvement of non-albicans Candida species such as Candida glabrata, Candida tropicalis, Candida krusei, Candida famata, Candida parapsilosis, and Candida spp.The risk factors for vaginal candidiasis include pregnancy, diabetes mellitus, frequent oral sexual intercourse, the use of tight synthetic underwear, systemic antibiotics, and immunodeficiency conditions.The prevalence of non-albicans Candida species and antifungal resistance, especially against azoles, is increasing.Certain risk factors should be monitored strictly, and there is a need for good awareness and systematic research in young women.The imbalanced composition of the vaginal microflora and genetic predisposition also play a role in the occurrence of vaginal candidiasis.
What is the prevalence of Candida albicans in women?5 answersThe prevalence of Candida albicans in women varies across different studies. In one study conducted in Iraq, the prevalence of C. albicans among married women with signs and symptoms of vaginitis was found to be 38.67%. Another study in Nigeria found that pregnant women had a higher prevalence of C. albicans (30.5%) compared to non-pregnant women (18%). A study in Rivers State, Nigeria reported a higher prevalence rate of candidiasis in pregnant women (29.4%) compared to non-pregnant women (13.68%). A study in Port-Harcourt, Nigeria found a prevalence of 64% for vaginal infections, with Candida albicans being the most prevalent species. Another study in Oyo State, Nigeria reported a prevalence of Candida species of 40%, with Candida albicans being the most common. Overall, these studies indicate that Candida albicans is a prevalent fungal infection among women, with varying prevalence rates depending on the population studied and the geographical location.
Does treatment with some anti-inflammatory drugs reduce germ tube formation in Candida albicans strains?4 answersTreatment with nonsteroidal anti-inflammatory drugs (NSAIDs) such as diclofenac and aspirin can reduce germ tube formation in Candida albicans strains. In tests for germ tube formation, sodium diclofenac reduced filamentation by 12.5%-5.1% and aspirin reduced filamentation by up to 85-45% depending on the strain. Aspirin, etodolac, and diclofenac were the most effective NSAIDs in inhibiting biofilm formation, with aspirin causing up to 95% inhibition. COX inhibitors, including diclofenac, significantly reduced fungal adhesion, biofilm formation, and yeast-hypha conversion in C. albicans. Diclofenac and aspirin also showed significant inhibition of germ tube formation in Candida strains. These findings suggest that the cyclooxygenase-dependent synthesis of fungal prostaglandins is important for germ tube formation and fungal virulence, and NSAIDs can effectively reduce germ tube formation in Candida albicans strains.
Positive role of candida albicans in human body?5 answersCandida albicans is a commensal fungal species that commonly colonizes the human body and has a positive role in nutrient absorption and inhibiting the growth of other pathogens in the digestive tract. However, when the balance of the intestinal flora is disrupted, Candida albicans can cause pathological conditions and spread throughout the body, leading to serious infections. The fungus interacts with epithelial cells, forming hyphae and secreting Candidalysin, a peptide toxin, which leads to host cell damage and immune activation. This activation triggers the production of inflammatory mediators and the recruitment of innate immune cells to clear the fungal infection. Candida albicans also exhibits proteome plasticity, allowing it to adapt and switch from harmless commensal to invasive pathogen. Overall, Candida albicans plays a complex role in the human body, with both beneficial and pathogenic effects depending on the host's immune fitness and the microenvironment.