Can epigenetic changes have a lasting impact on DNA transmission?
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Epigenetic changes can have a lasting impact on DNA transmission. Trained immunity in macrophages involves long-term retention of stimulus-induced histone post-translational modifications (PTMs) that persist for at least 14 cell divisions after stimulus washout . Early life stress and traumatic experiences can lead to epigenetic alterations in genes regulating the hypothalamus-pituitary-adrenal axis and the immune system, which may be transmitted to subsequent generations . Adverse experiences in mothers' childhoods can be correlated with DNA methylation in peripheral blood during pregnancy and in cord blood samples from their newborn infants, indicating enduring and transmitted impacts of mothers' adverse childhood experiences on DNA methylation . Infections, such as viruses and intracellular bacteria, can manipulate host cell functions through epigenetic mechanisms, which may persist even after the initial infection has been cleared . These findings suggest that epigenetic changes can have long-lasting effects on DNA transmission.
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44 Citations | Epigenetic changes can have a lasting impact on DNA transmission, as shown by the stable transmission of epigenetic modifications in the germline to the next generation. |
11 Citations | Epigenetic changes can have a lasting impact on DNA transmission, as shown in the study where adverse childhood experiences in mothers were correlated with DNA methylation in their newborn infants. |
| The paper does not directly address the lasting impact of epigenetic changes on DNA transmission. The paper focuses on the transmission of stimulus-induced epigenetic changes through cell division and the role of transcription factor activity in driving this transmission. | |
51 Citations | The paper discusses the potential for epigenetic changes to be transmitted across generations, suggesting that they can have a lasting impact on DNA transmission. |
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