Can XNA be used to treat or even cure genetic disease?
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Xeno nucleic acids (XNA) are artificial nucleic acid analogs that have the potential to be used as a drug for controlling genetic diseases . XNAzymes, which are similar to ribozymes, have been developed using XNA and have shown cleavage activity in cultured cells . XNAs, being structurally distinct from natural DNA and RNA, exhibit superior biological stability and chemical diversity, making them suitable for therapeutic applications . XNAs have unique physicochemical properties, including enhanced biological stability and increased hybridization, which make them promising candidates for chemically-modified DNAzymes capable of silencing disease-associated proteins . XNAzymes have also been shown to mediate transphosphorylation chemistry with multiple turnover activity, making them potential reagents in biomedical applications . Therefore, XNA has the potential to be used in the treatment and possibly even cure of genetic diseases.
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| Papers (4) | Insight |
|---|---|
| The paper does not directly address the use of XNA to treat or cure genetic diseases. The paper focuses on the development of XNAzymes for RNA cleavage in cells. | |
| The paper discusses XNAs as a possible route to chemically-modified DNAzymes that can silence the expression of disease-associated proteins. However, it does not specifically mention whether XNA can be used to treat or cure genetic diseases. | |
| The paper does not specifically mention the use of XNA to treat or cure genetic diseases. The paper focuses on the generation and application of functional XNA molecules, such as aptamers and enzymes, for various biomedical applications. | |
| The paper does not specifically mention the use of XNA for treating or curing genetic diseases. The paper focuses on the applications of XNA in encoding nonstandard amino acids and producing XNAzymes. |
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