Cannabinoids inhibit the synaptic uptake of adenosine and dopamine in the rat and mouse striatum
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Cannabinoids have been found to inhibit the synaptic uptake of adenosine and dopamine in the rat and mouse striatum . These effects are not mediated by the cannabinoid CB(1) receptors . The inhibitory effect on adenosine uptake is generally more potent than that on dopamine uptake . The inhibitory effects on both adenosine and dopamine uptake are not prevented by the cannabinoid CB(1) receptor antagonist/inverse agonist, LY320135 . Furthermore, these effects are maintained in cannabinoid CB(1) receptor knockout mice . The inhibitory effects on dopamine uptake are observed in both in vitro and in vivo experiments . Overall, these findings suggest that cannabinoids can modulate the synaptic uptake of adenosine and dopamine in the striatum, providing an additional mechanism to consider when interpreting the synaptic effects of cannabinoids .
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76 Citations | The given text does not provide any information about the effects of cannabinoids on the synaptic uptake of adenosine and dopamine in the rat and mouse striatum. |
40 Citations | The paper does not provide information about the inhibition of adenosine uptake by cannabinoids in the striatum. |
6 Citations | The paper does not mention the effect of cannabinoids on the synaptic uptake of adenosine and dopamine in the striatum. |
68 Citations | Yes, cannabinoids inhibit the synaptic uptake of adenosine and dopamine in the rat and mouse striatum. |
Open access•Journal Article 143 Citations | The paper does not mention the inhibition of adenosine uptake by cannabinoids. It only mentions the inhibition of dopamine uptake in the corpus striatum. |
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