J
James L. Roberts
Researcher at Trinity University
Publications - 183
Citations - 12008
James L. Roberts is an academic researcher from Trinity University. The author has contributed to research in topics: Gene expression & Gonadotropin-releasing hormone. The author has an hindex of 57, co-authored 180 publications receiving 11684 citations. Previous affiliations of James L. Roberts include Veterans Health Administration & University of Texas Health Science Center at San Antonio.
Papers
More filters
Journal ArticleDOI
Immortalization of hypothalamic GnRH by genetically targeted tumorigenesis
Pamela L. Mellon,Jolene J. Windle,Paul C. Goldsmith,Cheryl A. Padula,James L. Roberts,Richard I. Weiner +5 more
TL;DR: These immortalized cells will provide an invaluable model system for study of hypothalamic neurosecretory neurons that regulate reproduction and demonstrates the feasibility of immortalizing differentiated neurons by targeting tumorigenesis in transgenic mice to specific neurons of the CNS.
Journal ArticleDOI
Hypothalamic Pro-Opiomelanocortin mRNA Is Reduced By Fasting in ob/ob and db/db Mice, but Is Stimulated by Leptin
Tooru M. Mizuno,Steven P. Kleopoulos,Hugo Bergen,James L. Roberts,Catherine A. Priest,Charles V. Mobbs +5 more
TL;DR: In this paper, the pro-opiomelanocortin (POMC) gene expression was found to be inhibited by fasting in normal mice or in models of obesity characterized by leptin insufficiency ( ob/ob ) or leptin insensitivity ( db/db ).
Journal ArticleDOI
Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals
Qian Gao,Gábor Mezei,Yongzhan Nie,Yan Rao,Cheol Soo Choi,Ingo Bechmann,Csaba Leranth,Dominique Toran-Allerand,Catherine A. Priest,James L. Roberts,Xiao-Bing Gao,Charles V. Mobbs,Gerald I. Shulman,Sabrina Diano,Tamas L. Horvath +14 more
TL;DR: It is reported that estradiol (E2) triggers a robust increase in the number of excitatory inputs to POMC neurons in the arcuate nucleus of wild-type rats and mice, which supports the notion that synaptic plasticity of arcsuate nucleus feeding circuits is an inherent element in body weight regulation.
Journal ArticleDOI
Cloning and functional expression of a mouse gonadotropin-releasing hormone receptor
Manami Tsutsumi,Wei Zhou,Robert P. Millar,Pamela L. Mellon,James L. Roberts,Colleen A. Flanagan,Kewen Dong,Boaz Gillo,Stuart C. Sealfon +8 more
TL;DR: The cloning of a cDNA representing the mouse GnRHR is reported and its identity is confirmed using Xenopus oocyte expression and it is reported that the nucleotide sequence encodes a 327-amino acid protein which has the seven putative transmembrane domains characteristic of G protein-coupled receptors, but which lacks a typical intracellular C-terminus.
Journal ArticleDOI
Transthyretin: a choroid plexus-specific transport protein in human brain. The 1986 S. Weir Mitchell award.
Joseph Herbert,Josiah N. Wilcox,Kim-Thu C. Pham,Robert T. Fremeau,Massimo Zeviani,Andrew J. Dwork,D R Soprano,Adina Makover,DeWitt S. Goodman,Earl A. Zimmerman,James L. Roberts,Eric A. Schon +11 more
TL;DR: Within the mammalian CNS, TTR is the first known protein synthesized solely by the choroid plexus, suggesting a special role for TTR in the brain or CSF.