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Comprehensive Epigenetic Profiling with decitabine?

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Decitabine, a demethylating drug, is crucial in cancer therapy due to its efficacy in treating various cancers, including acute myelogenous leukemia (AML). Studies highlight its role in altering DNA methylation patterns, impacting gene expression and treatment response. Decitabine's synergistic effects with other treatments, like TRAIL, have shown promise in enhancing anti-tumor responses in gastric cancer cells by upregulating death receptor 4 (DR4) through epigenetic modifications. Furthermore, single-cell transposable element methylation sequencing (scTEM-seq) provides a cost-effective method to assess global DNA methylation levels, aiding in understanding the heterogeneous regulation of DNA methylation. These findings underscore the importance of comprehensive epigenetic profiling with decitabine to optimize cancer treatment strategies and improve patient outcomes.

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Open access•Journal Article•DOI Decitabine enhances the tumoricidal potential of TRAIL via the epigenetic regulation of death receptor 4 in gastric cancer Lin Li, Qian Niu, Yuanmin Zhu, Biao Fan, Guibin Yang - Show less +4 more 01 Jan 2022-Journal of gastrointestinal oncology	Decitabine enhances TRAIL efficacy in gastric cancer by upregulating DR4 through epigenetic modifications, showcasing its potential as a sensitizing agent for novel treatment strategies.
Open access•Journal Article•DOI DNA methylation signature predicts cancer response to demethylation agents from profiling diverse cancer cell lines Jan Marie Fritz 18 Jun 2022 1 Citations	Decitabine shows potent demethylation effects in diverse cancer cell lines, with a predictive DNA methylation signature for treatment response, especially in hematopoietic/lymphatic cancers, aiding in personalized therapy.
Open access•Posted Content•DOI SINEultaneous profiling of epigenetic heterogeneity and transcriptome in single cells Kooper V Hunt, Sean Burnard, Ellise A Roper, Danielle R. Bond, Matthew D. Dun, Nicole M. Verrills, Anoop K Enjeti, Heather J. Lee - Show less +7 more 25 Mar 2021-bioRxiv	Single-cell transposable element methylation sequencing (scTEM-seq) with decitabine treatment reveals global DNA methylation heterogeneity and altered gene expression, enhancing understanding of epigenetic regulation in cancer.
Posted Content•DOI Data from A Single Nucleotide Polymorphism Chip-Based Method for Combined Genetic and Epigenetic Profiling: Validation in Decitabine Therapy and Tumor/Normal Comparisons Daniel Duzdevich 30 Mar 2023	A single nucleotide polymorphism chip-based method (MSNP) allows comprehensive genetic and epigenetic profiling, validated in decitabine therapy for leukemia and tumor/normal tissue comparisons, enhancing understanding of epigenetic changes.

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