Do changes in functional connectivity over time reflect treatment effects of Alzheimer's disease?
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Changes in functional connectivity over time may reflect treatment effects of Alzheimer's disease. In a study by Péran et al., the effects of donepezil treatment on healthy brains were investigated, revealing significant differences in intrinsic functional connectivity compared to placebo treatment . Malotaux et al. found that patients with mild cognitive impairment (MCI) progressing towards dementia showed increasing intra-default mode network (DMN) connectivity over time, suggesting aberrant synchronization in the symptomatic stages of Alzheimer's disease . However, a study by Clayton et al. using data from a multicenter, longitudinal setting found no changes in functional connectivity over time in the placebo group, indicating that functional connectivity may not be sensitive enough to detect disease progression in patients . Therefore, while some studies suggest that changes in functional connectivity over time may reflect treatment effects, further research is needed to fully understand the relationship between functional connectivity and Alzheimer's disease progression.
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| The provided paper is about the effects of dimethyl fumarate treatment in multiple sclerosis, not Alzheimer's disease. Therefore, there is no information in the paper about changes in functional connectivity reflecting treatment effects of Alzheimer's disease. | |
30 Citations | The provided paper does not mention anything about treatment effects of Alzheimer's disease or changes in functional connectivity over time. |
5 Citations | The provided paper does not mention Alzheimer's disease or treatment effects. |
01 Dec 2021 | The paper does not provide evidence of changes in functional connectivity reflecting treatment effects of Alzheimer's disease. |
1 Citations | The provided paper does not mention anything about treatment effects of Alzheimer's disease. |
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