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Adrian Ivanoiu
Researcher at Université catholique de Louvain
Publications - 105
Citations - 4683
Adrian Ivanoiu is an academic researcher from Université catholique de Louvain. The author has contributed to research in topics: Dementia & Frontotemporal dementia. The author has an hindex of 27, co-authored 94 publications receiving 3891 citations. Previous affiliations of Adrian Ivanoiu include Cliniques Universitaires Saint-Luc & Catholic University of Leuven.
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Journal ArticleDOI
Improved discrimination of AD patients using beta-amyloid((1-42)) and tau levels in CSF
Frank Hulstaert,Kaj Blennow,Adrian Ivanoiu,HC Schoonderwaldt,Matthias Riemenschneider,P.P. De Deyn,C. Bancher,Patrick Cras,Jens Wiltfang,Pankaj Mehta,Khalid Iqbal,Hans Pottel,Eugeen Vanmechelen,Hugo Vanderstichele +13 more
TL;DR: The combined measure of CSF Aβ42 and tau meets the requirements for clinical use in discriminating AD from normal aging and specific neurologic disorders.
Journal ArticleDOI
18F-flutemetamol amyloid imaging in Alzheimer disease and mild cognitive impairment : a phase 2 trial.
Rik Vandenberghe,Rik Vandenberghe,Koen Van Laere,Adrian Ivanoiu,Eric Salmon,Christine Bastin,Eric Triau,Steen G. Hasselbalch,Ian Law,Allan R. Andersen,Alex Korner,Lennart Minthon,Gaëtan Garraux,Natalie Nelissen,Guy Bormans,Christopher Buckley,Rikard Owenius,Lennart Thurfjell,Gill Farrar,David J. Brooks,David J. Brooks +20 more
TL;DR: Validation of the 18F‐labeled PIB derivative18F‐flutemetamol could significantly enhance access to in vivo β‐amyloid imaging technology.
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Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease : A Longitudinal Study
Bernard Hanseeuw,Bernard Hanseeuw,Rebecca A. Betensky,Heidi I.L. Jacobs,Heidi I.L. Jacobs,Aaron P. Schultz,Jorge Sepulcre,J. Alex Becker,Danielle M. Cosio,Michelle E. Farrell,Yakeel T. Quiroz,Elizabeth C. Mormino,Elizabeth C. Mormino,Rachel F. Buckley,Rachel F. Buckley,Rachel F. Buckley,Kathryn V. Papp,Kathryn V. Papp,Rebecca A Amariglio,Rebecca A Amariglio,Ilse Dewachter,Ilse Dewachter,Adrian Ivanoiu,Adrian Ivanoiu,Willem Huijbers,Willem Huijbers,Trey Hedden,Gad A. Marshall,Gad A. Marshall,Jasmeer P. Chhatwal,Dorene M. Rentz,Dorene M. Rentz,Reisa A. Sperling,Reisa A. Sperling,Keith A. Johnson,Keith A. Johnson +35 more
TL;DR: amyloid accumulation was associated with subsequent tau accumulation, and this sequence of successive amyloid and tau changes in neocortex was found to mediate the association of initial amyloids with final cognition, measured 7 years later.
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The C9orf72 repeat size correlates with onset age of disease, DNA methylation and transcriptional downregulation of the promoter
Ilse Gijselinck,S. Van Mossevelde,J. van der Zee,Anne Sieben,Anne Sieben,Sebastiaan Engelborghs,J. De Bleecker,Adrian Ivanoiu,Olivier Deryck,Dieter Edbauer,Dieter Edbauer,Ming Zhang,Bavo Heeman,Veerle Bäumer,M Van den Broeck,Maria Mattheijssens,K. Peeters,Ekaterina Rogaeva,P. De Jonghe,Patrick Cras,Jean-Jacques Martin,P.P. De Deyn,Marc Cruts,C. Van Broeckhoven +23 more
TL;DR: It is shown that increased methylation of CpGs in the C9orf72 promoter may explain how an increasing G4C2 size lead to loss-of-function without excluding repeat length-dependent toxic gain- of-function.
Journal ArticleDOI
Comparison of regional cerebral blood flow and glucose metabolism in the normal brain: effect of aging
M. Bentourkia,Anne Bol,Adrian Ivanoiu,Daniel Labar,Merence Sibomana,A. Coppens,Christian Michel,Guy Cosnard,Anne De Volder +8 more
TL;DR: A decline in rCBF and rC MRGlc values and a coupling between CBF and CMRGlc as a function of age is indicated and found in all brain regions for young and old subjects.