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Open accessJournal ArticleDOI
Kenshi Yamasaki, Richard L. Gallo 
147 Citations
Thus, current research suggests that understanding how antimicrobial peptides modify susceptibility to microbes, influence skin inflammation, and modify wound healing, provides greater insight into the pathophysiology of skin disorders and offers new therapeutic opportunities.
Sagging and wrinkled skin are features of chronic sun-damaged and aged uncared skin, and they are mainly associated with the deterioration of collagen and elastic fibers.
This investigation showed that the studied peptides have biological effects, testifying the stimulation of reparative processes in the skin under their control.
Apart from possible fields of application, these peptides appear suited as an example of the paradigm of translational medicine for skin diseases which is today seen as a ‘two-way road’ – from bench to bedside and backwards from bedside to bench.
The mechanism of sagging is a very complicated process, which depends on many factors.