Do sleep alterations predict relapses in multiple sclerosis?
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Sleep alterations have been found to potentially predict relapses in multiple sclerosis (MS) patients. Studies have shown that sleep disturbances are prevalent in MS patients , with a negative impact on the clinical outcome of the disease, especially in relation to fatigue. Furthermore, the study of circadian activity rhythm in early relapsing-remitting MS patients revealed specific alterations, indicating a peak in motor activity that could be linked to hyperactive hypothalamus-pituitary-adrenal axis and higher cortisol awakening response. Additionally, research has highlighted a significant association between sleep quality and depression, anxiety, and stress in MS patients, with these factors being predictors of the deterioration of sleep quality. Therefore, addressing sleep disturbances in MS patients may play a crucial role in managing the disease and potentially predicting relapses.
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Open access•Journal Article 25 Citations | Not addressed in the paper. |
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21 Citations | Yes, sleep disturbances can act as a triggering factor for relapse in multiple sclerosis patients, as poor sleep quality was associated with acute relapse episodes in the study. |
5 Citations | Not addressed in the paper. |
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