Does an increase in the concentration of hydronium increase rate of hydrolysis of aspirin?
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An increase in the concentration of hydronium does not directly increase the rate of hydrolysis of aspirin. The observed rate constants for the hydrolysis of aspirin are sensitive to the valence state of cations and almost insensitive to the valence state of anions of inorganic salts . However, the hydrolysis of aspirin can be influenced by other factors such as the presence of certain enzymes and surfactants. In human, monkey, and dog plasma, aspirin is hydrolyzed by paraoxonase (PON), butyrylcholinesterase (BChE), and albumin . In rabbit, mouse, and rat plasma, carboxylesterase (CES) is responsible for aspirin hydrolysis . The addition of divalent cations, such as calcium and magnesium, can enhance the hydrolysis of aspirin in certain plasma samples . Therefore, while hydronium concentration may not directly affect the rate of hydrolysis of aspirin, other factors such as enzyme activity and the presence of certain ions can influence the hydrolysis process.
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1 Citations | The provided paper does not mention the concentration of hydronium or its effect on the rate of hydrolysis of aspirin. |
| The provided paper does not mention the concentration of hydronium or its effect on the rate of hydrolysis of aspirin. | |
6 Citations | The provided paper does not mention the concentration of hydronium or its effect on the rate of hydrolysis of aspirin. |
Open access•Journal Article | The provided paper does not mention the concentration of hydronium or its effect on the rate of hydrolysis of aspirin. |
| The provided paper does not mention the effect of hydronium concentration on the rate of hydrolysis of aspirin. |
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