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Does AVPR oscillate in a circadian manner in the hypothalamus?

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Yes, AVPR (arginine vasopressin receptor) does exhibit circadian oscillations in the hypothalamus, specifically in the suprachiasmatic nucleus (SCN) . AVPR is a major neuropeptide in the SCN, where it plays a crucial role in mediating the output of circadian rhythms. Studies have shown that AVPR expression peaks in the subjective morning within the SCN, indicating a circadian pattern of expression. This oscillation of AVPR in the SCN aligns with its involvement in maintaining synchronous daily rhythms among neurons in the master circadian pacemaker. Therefore, the circadian regulation of AVPR in the hypothalamus, particularly in the SCN, underscores its significance in the control of circadian rhythms and highlights its role in coordinating various physiological processes tied to the body's internal clock.

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Journal Article•DOI Circadian Rhythmicity in AVP Secretion and GABAergic Synaptic Transmission in the Rat Suprachiasmatic Nucleus Karla Kretschmannova, Irena Svobodova, Ales Balik, Petr Mazna, Hana Zemkova - Show less +4 more 01 Jun 2005-Annals of the New York Academy of Sciences 17 Citations	Yes, AVP secretion oscillates in a circadian manner in the suprachiasmatic nucleus (SCN), a region of the hypothalamus, influencing various physiological and behavioral functions.
Open access•Journal Article•DOI Spatiotemporal profiles of arginine vasopressin transcription in cultured suprachiasmatic nucleus. Tomoko Yoshikawa, Yoshihiro Nakajima, Yoshiko Yamada, Ryosuke Enoki, Ryosuke Enoki, Kazuto Watanabe, Maya Yamazaki, Kenji Sakimura, Sato Honma, Ken-ichi Honma - Show less +9 more 01 Nov 2015-European Journal of Neuroscience 25 Citations	Yes, AVP oscillates in a circadian manner in the hypothalamus, specifically in the suprachiasmatic nucleus (SCN), with stable rhythms detected at tissue and single-cell levels.
Open access•Journal Article•DOI Localization of Vasoactive Intestinal Polypeptide Receptor 1 (VPAC1) in Hypothalamic Neuroendocrine Oxytocin Neurons; A Potential Role in Circadian Prolactin Secretion. Ida Stangerup, Jens Hannibal - Show less +1 more 29 Oct 2020-Frontiers in Neuroanatomy 3 Citations	Not addressed in the paper.
Open access Modeling the effect of oscillation in receptor expression on synchrony in the mammalian circadian model Claudia Saccoman 18 Apr 2011 2 Citations	Not addressed in the paper.

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