K
Ken-ichi Honma
Researcher at Hokkaido University
Publications - 243
Citations - 11150
Ken-ichi Honma is an academic researcher from Hokkaido University. The author has contributed to research in topics: Circadian rhythm & Suprachiasmatic nucleus. The author has an hindex of 60, co-authored 240 publications receiving 10277 citations. Previous affiliations of Ken-ichi Honma include Science Council of Japan.
Papers
More filters
Journal ArticleDOI
Dec1 and Dec2 are regulators of the mammalian molecular clock
Sato Honma,Takeshi Kawamoto,Yumiko Takagi,Katsumi Fujimoto,Fuyuki Sato,Mitsuhide Noshiro,Yukio Kato,Ken-ichi Honma +7 more
TL;DR: Dec1 and Dec2 are regulators of the mammalian molecular clock, and form a fifth clock-gene family that repressed Clock/Bmal1-induced transactivation of the mouse Per1 promoter through direct protein–protein interactions with Bmal1 and/or competition for E-box elements.
Journal ArticleDOI
Melatonin induces γ-glutamylcysteine synthetase mediated by activator protein-1 in human vascular endothelial cells
Yoshishige Urata,Sato Honma,Shinji Goto,Sachiko Todoroki,Tetsuya Iida,Sungsam Cho,Ken-ichi Honma,Takahito Kondo +7 more
TL;DR: Induction of GSH synthesis bymelatonin protects cells against oxidative stress and regulates cell proliferation, suggesting induction of cell arrest by melatonin requires GSH.
Journal ArticleDOI
Separate oscillating cell groups in mouse suprachiasmatic nucleus couple photoperiodically to the onset and end of daily activity.
TL;DR: Findings indicate that three oscillating cell groups in the SCN constitute regionally specific circadian oscillations, and at least two of them are involved in photoperiodic response of behavioral rhythm.
Journal ArticleDOI
Two distinct oscillators in the rat suprachiasmatic nucleus in vitro
TL;DR: The results indicate that the arginine vasopressin and vasoactive intestinal polypeptide release are under control of different circadian oscillators.
Journal ArticleDOI
Human blood metabolite timetable indicates internal body time
Takeya Kasukawa,Masahiro Sugimoto,Masahiro Sugimoto,Akiko Hida,Yoichi Minami,Masayo Mori,Sato Honma,Ken-ichi Honma,Kazuo Mishima,Tomoyoshi Soga,Hiroki R. Ueda +10 more
TL;DR: This work constructed a 1.5-d reference timetable of oscillating metabolites in human blood samples with 2-h sampling frequency and accurately determined internal body time within 3 h from just two anti-phase blood samples, enabling highly optimized and personalized medicine.