Does BCL2 have a promoting effect on autophagy?
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BCL2 has a dual role in autophagy regulation. In osteoblasts, BCL2 expression is inhibited by lactoferrin, leading to enhanced autophagy activity . On the other hand, in osteoclast precursors (OCPs), BCL2 phosphorylation at the Ser70 site promotes autophagy and osteoclastogenesis . In hepatocellular carcinoma (HCC), tissue factor (TF) upregulates BCL2 expression, inhibiting autophagy and promoting HCC tumorigenesis . In pancreatic mucinous cystadenocarcinoma (MCC), abnormal autophagy activation contributes to the migration and invasion of MCC cells, and BCL2 is identified as a downstream target gene of miR-224-5p, which regulates autophagy signaling . Therefore, the role of BCL2 in autophagy regulation is context-dependent, with both inhibitory and promoting effects observed in different cell types and diseases.
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| Papers (4) | Insight |
|---|---|
| The paper states that BCL2 phosphorylation at the Ser70 site promotes autophagy in osteoclast precursor cells (OCPs) under RANKL induction. Therefore, BCL2 has a promoting effect on autophagy. | |
2 Citations | The paper states that BCL2 is a key inhibitor of autophagy responses, suggesting that BCL2 does not have a promoting effect on autophagy. |
| The paper states that lactoferrin inhibits BCL2 expression in osteoblasts, which further enhances Beclin1-dependent autophagy activation. Therefore, BCL2 does not have a promoting effect on autophagy. | |
| The paper states that BCL2 phosphorylation at the Ser70 site promotes autophagy in osteoclast precursor cells (OCPs) under RANKL induction. Therefore, BCL2 has a promoting effect on autophagy. |
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