Does CAH cause an increased production of adrenal hormones?
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CAH is a group of disorders characterized by enzymatic defects in cortisol biosynthesis. These defects can affect the glucocorticoid, mineralocorticoid, and androgen biosynthesis pathways, leading to low cortisol production and accumulation of steroid hormone precursors. This results in adrenal hyperplasia and usually hyperandrogenemia . In individuals with CAH, there is elevated adrenal androgen production due to defective steroidogenesis . Adult males with CAH experience a significant reduction in serum concentrations of Leydig cell-derived hormones, such as insulin-like factor 3 (INSL3) and testosterone, despite hormone replacement therapy . CAH is associated with enzyme deficiencies, including 21-hydroxylase, 11-beta-hydroxylase, 3-beta-hydroxysteroid dehydrogenase, and 17-alpha-hydroxylase deficiencies . These findings indicate that CAH does cause an increased production of adrenal hormones, specifically androgens, due to enzymatic defects in cortisol biosynthesis.
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| Papers (3) | Insight |
|---|---|
| Yes, CAH causes an increased production of adrenal androgen hormones. (Source: "This causes an accumulation of adrenocorticotrophic hormone (ACTH) secondary to negative feedback, which results in overstimulation of the adrenal cortex and increased adrenal androgen production") | |
01 Jan 2021 | Yes, CAH causes an increased production of adrenal hormones due to low cortisol production stimulating the secretion of corticotrophin releasing hormone (CRH) and adrenocorticotrophic hormone (ACTH), leading to adrenal hyperplasia and accumulation of steroid hormone precursors. |
| The paper does not provide information about whether CAH causes an increased production of adrenal hormones. |
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