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Does pregnelone sulphate injection in the hindpaw?

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Pregnenolone sulfate (PS) injection in the hindpaw is not specifically addressed in the provided contexts. However, the research papers discuss the effects of PS on memory enhancement, pituitary prolactin synthesis, brain metabolization to neuroactive compounds, and regulatory effects on neurotransmitter release. PS injections in various brain regions like the amygdala, hippocampus, and caudate nucleus have shown memory enhancement effects . PS has been found to upregulate pituitary prolactin synthesis via MAPK signaling pathways . Additionally, PS metabolization in the brain to compounds like allopregnanolone has been linked to cognitive effects . Furthermore, PS has been associated with cognitive preservation and enhancement in aged rats, potentially through interactions with cholinergic systems . While hindpaw injection effects are not directly discussed, these findings highlight the diverse neurological and cognitive impacts of PS administration.

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Open access•Journal Article•DOI Neurosteroids: deficient cognitive performance in aged rats depends on low pregnenolone sulfate levels in the hippocampus. Monique Vallée, W Mayo, Muriel Darnaudéry, C. Corpéchot, Jacques Young, Muriel Koehl, M. Le Moal, Etienne-Emile Baulieu, Paul Robel, H. Simon - Show less +9 more 23 Dec 1997-Proceedings of the National Academy of Sciences of the United States of America 304 Citations	Not addressed in the paper.
Open access•Journal Article•DOI Pregnenolone sulfate regulates prolactin production in the rat pituitary. Eun-Jin Kang, So-Hye Hong, Jae-Eon Lee, Seungchul Kim, Hoe-Saeng Yang, Pyong in Yi, Sang-Myeong Lee, Beum-Soo An - Show less +7 more 01 Sep 2016-Journal of Endocrinology 5 Citations	Not addressed in the paper.
Book Chapter•DOI Subchapter 96A – Pregnenolone Sulfate Kazuyoshi Tsutsui, Shogo Haraguchi - Show less +1 more 01 Jan 2016	Not addressed in the paper.
Journal Article•DOI Pregnenolone sulfate antagonizes dizocilpine amnesia: role for allopregnanolone. D. L. Cheney, D. Uzunov, Alessandro Guidotti - Show less +2 more 21 Aug 1995-Neuroreport 67 Citations	Not addressed in the paper.
Open access•Journal Article•DOI Pregnenolone sulfate enhances post-training memory processes when injected in very low doses into limbic system structures: the amygdala is by far the most sensitive. James F. Flood, John E. Morley, Eugene Roberts - Show less +2 more 07 Nov 1995-Proceedings of the National Academy of Sciences of the United States of America 179 Citations	Not addressed in the paper.

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