Does psilocybin create neurons?
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These results are consistent with the idea that psilocybin therapy revives emotional responsiveness on a neural and psychological level, which may be a key treatment mechanism for psychedelic therapy. | |
The present data do not provide support for this concern and are consistent with recently renewed clinical research suggesting possible therapeutic applications of psilocybin. | |
717 Citations | These data are consistent with animal studies and provide the first evidence in humans that psilocybin-induced psychosis is due to serotonin-2A receptor activation, independently of dopamine stimulation. |
Overall, the results demonstrate that psilocybin-evoked synaptic rewiring in the cortex is fast and enduring, potentially providing a structural trace for long-term integration of experiences and lasting beneficial actions. | |
To many people brought up in the Reagan drug war era with the ‘drugs fry your brain’ message, psilocybin may seem a strange and possibly even a dangerous drug treatment of serious mental illness. | |
Psilocybin had no effect on low-level visually induced and motor-induced gamma-band oscillations, suggesting that some basic elements of oscillatory brain activity are relatively preserved during the psychedelic experience. | |
35 Citations | Evidence is also presented that the central nervous system effects of psilocybin are exerted only after its transformation to the 4-hydroxy analog, psilocin. |
37 Citations | Our findings provide further evidence for the rapid plasticity-promoting effects of psilocybin. |
69 Citations | These experiments indicate that possibly in the intact animal psilocybin is rapidly dephosphorylated and is pharmacologically active as psilocin, while the duration of the effect might be controlled by the oxidation of the latter compound to an o-quinone type of structure. |
35 Citations | The results of this study demonstrate the rapid dephosphorylation of psilocybin by the intact mouse. |
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What psilocybin brain chemistry?4 answersPsilocybin is a chemical found in certain mushrooms that has high affinity for serotonin receptors in the brain. It stimulates serotonin 5-HT1A, 5-HT2A, and 5-HT2C receptors, which are located in various areas of the brain, including the cerebral cortex and thalamus. Psilocybin has been studied for its potential therapeutic effects in various mental health conditions, including depression, anxiety disorders, obsessive-compulsive disorder, alcohol addiction, and tobacco addiction. Recent research has also focused on understanding the enzymatic basis of psilocybin biosynthesis, which involves four enzymes: PsiD, PsiK, PsiM, and PsiH. These enzymes are responsible for the synthesis and metabolism of psilocybin, and their characterization may pave the way for biotechnological production of psilocybin. Additionally, studies have shown that psilocybin induces changes in brain connectivity, particularly in the default mode and executive networks, which are characteristic of psychotic patients.
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