Does vitamin C influence the immune system?
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Vitamin C has been found to have a positive influence on the immune system. Studies have shown that vitamin C can enhance the immunity of the novel coronavirus, although further research is needed to determine the specific mechanism, optimal dosage, and timing of administration . Vitamin C plays a crucial role in the differentiation of dendritic cells (DCs), which are important in bridging the adaptive and innate immune responses. It triggers demethylation at NF-kB/p65 binding sites, leading to the upregulation of immune response-related genes during DC maturation. Vitamin C also increases TNFβ production in DCs and enhances their ability to stimulate the proliferation of antigen-specific T cells, suggesting its potential in improving DC-based cell therapies . Deficiency in vitamin C can compromise the immune response, and studies have explored its role in the health of white blood cells and the expression of immune system-related genes. Vitamin C supplementation has been shown to improve immune reconstitution and decrease the frequency of infections after hematopoietic stem cell transplantation .
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| Papers (5) | Insight |
|---|---|
01 Sep 2022 2 Citations | Yes, vitamin C influences the immune system by improving the reconstitution of natural killer (NK) lymphocytes after hematopoietic stem cell transplantation (HSCT). |
| Yes, according to the paper, vitamin C supplementation significantly elevated levels of interferon (IFN)-γ, interleukin (IL)-4, and IL-5 in vaccinated mice, indicating that vitamin C influences the immune response. | |
| Yes, vitamin C influences the immune system by playing a role in immune system regulation, affecting the health of white blood cells and the expression of genes involved in immunity. | |
28 Apr 2023 | Yes, vitamin C plays a highly regulatory role in the immune system by enhancing the functions of immune cells such as NK cells, T cells, B cells, neutrophils, and macrophages. |
| Yes, vitamin C influences the immune system by triggering epigenomic and transcriptomic reprogramming in dendritic cells, leading to enhanced immunogenic responses. |
Related Questions
What is the recommended daily intake of vitamin C for individuals with a low immune system?5 answersIndividuals with a compromised immune system may benefit from a higher daily intake of vitamin C. Current recommendations suggest a daily intake of at least 200 mg of vitamin C for optimal immune function and overall health, especially for individuals with immune system challenges. Vitamin C plays a crucial role in supporting various aspects of both the innate and adaptive immune system, including enhancing the function of white blood cells, such as neutrophils and lymphocytes, which are essential for fighting infections and maintaining immune health. Adequate vitamin C levels are vital for immune defense, promoting cellular functions, supporting barrier functions against pathogens, and enhancing microbial killing, all of which are crucial for individuals with a weakened immune system.
How does vitamin C affect the immune system?5 answersVitamin C plays a crucial role in modulating the immune system through various mechanisms. Studies have shown that vitamin C enhances cancer immunotherapy by boosting the immunogenic properties of dendritic cells and promoting cancer immunity. Additionally, vitamin C supplementation has been found to elevate levels of interferon and interleukins, essential components of immune responses, during vaccination against rabies virus. Furthermore, high-dose vitamin C supplementation post hematopoietic stem cell transplantation improves the reconstitution of natural killer cells and CD3+ lymphocytes, leading to enhanced immune function and reduced infection frequency. Overall, vitamin C's impact on the immune system includes enhancing immune responses, promoting antigen presentation, and improving immune cell function, highlighting its importance in maintaining a robust immune system.
Does this article refer to the effect of ascorbic acid on immunotherapy?5 answersYes, the articles collectively discuss the impact of ascorbic acid (vitamin C) on immunotherapy. Ascorbic acid has been shown to enhance the efficacy of immunotherapy by targeting hypoxia-induced CD8+ T cell dysfunction, increasing T cell infiltration, cytokine expression, and chemokine levels. Additionally, the loss of TET2 function in renal cancer cells can hinder antitumor immunity, which can be counteracted by ascorbic acid supplementation. Furthermore, studies have demonstrated that ascorbic acid plays a role in modulating immune responses by affecting immune cell infiltration and delaying cancer growth in a T cell-dependent manner. These findings highlight the potential of incorporating ascorbic acid into immunotherapeutic strategies to improve treatment outcomes for cancer patients.
Does this article refer to the effect of vitamin C on immunotherapy?5 answersVitamin C has been shown to have an effect on immunotherapy in multiple studies. Ma et al. demonstrated that the delivery of vitamin C at the tumor site can induce oxidative toxicity and promote the infiltration of cytotoxic T lymphocytes, enhancing immune checkpoint blocking therapy. Kouakanou et al. discussed the role of vitamin C in modulating the immune system and its potential as an adjunct to immune-based anti-cancer therapies. Morante-Palacios et al. investigated the epigenomic and transcriptomic reprogramming orchestrated by vitamin C in dendritic cell differentiation and maturation, suggesting its potential to improve cell therapies. Magrì et al. showed that high-dose vitamin C modulates the tumor microenvironment and enhances the antiproliferative effect of T cell-dependent immune responses, suggesting its potential in combination with immune checkpoint therapy. Kouakanou et al. also explored the effects of vitamin C on the proliferation and effector function of γδ T cells, highlighting its potential in adoptive immunotherapy.
What are the effects of vitamin A supplementation on the immune system?4 answersVitamin A supplementation has been shown to have a significant immune-modulatory effect. It plays a crucial role in maintaining growth, vision, and enhancing mucosal immunity. Vitamin A deficiency impairs both innate and adaptive immunity, leading to increased severity of infections and higher mortality rates. Vitamin A and its metabolites modulate the balance between Th1 and Th2 immunity, and vitamin D expresses protective effects on the innate immune system and inhibitory effects on adaptive immunity. Vitamin A can be used as a supplement in the treatment of diseases such as cancer and autoimmune diseases, but long-term consumption in high doses can have adverse effects. Understanding how vitamin A controls immunity is crucial for curbing the mortality and morbidity associated with vitamin A deficiency and exploiting its immune-enhancing capacity.
Does high dose vitamin C boost the immune system?5 answersHigh-dose vitamin C supplementation has been shown to improve immune function and enhance immune reconstitution after hematopoietic stem cell transplantation (HSCT). However, the use of high-dose vitamin C as a prophylaxis for viral diseases in a well-nourished population is not supported by the literature. Vitamin C has been found to directly impair cancer cell growth and modulate anticancer immune responses, suggesting its potential in combination with immune checkpoint therapy for cancer treatment. In the context of respiratory viral infections, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), high-dose vitamin C therapy has been shown to be safe and effective in reducing morbidity and mortality. Vitamin C supplementation may also support healthy immune function during infection, with intravenous administration potentially decreasing mortality in patients with severe pneumonia.