Dopamine may modulate the functional parameters of working memory circuits subserving effortful cognition in PArkinsons disease
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Dopaminergic medication plays a crucial role in modulating the functional parameters of working memory circuits in Parkinson's disease (PD). Studies suggest that dopamine impacts cognition by influencing frontoparietal-basal ganglia cognitive control circuits, with aberrant signaling normalized by medication. Dopamine appears to improve executive control, aiding in the ability to ignore and update information, while not affecting information maintenance over time. Additionally, decreased dopamine levels in PD patients are associated with cognitive deficits, including working memory impairments, potentially due to underlying dopaminergic dysfunction in cognitive circuits. Furthermore, alterations in beta bursting dynamics in caudate and dorsolateral prefrontal cortex during working memory encoding are linked to memory impairment in PD patients. These findings collectively highlight the significant role of dopamine in modulating cognitive functions, particularly working memory, in Parkinson's disease.
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| Papers (4) | Insight |
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| Dopamine modulation affects working memory circuits in Parkinson's disease, with decreased beta bursts in caudate and DLPFC correlating with memory impairment, suggesting a role in cognitive dysfunction. | |
| Dopamine modulation in dorsolateral prefrontal cortex beta power dynamics influences working memory encoding deficits in Parkinson's Disease, potentially offering targets for neuromodulation to improve cognitive function. | |
26 Citations | Dopamine in Parkinson's disease modulates effortful cognition by reducing interference but not information decay, impacting updating and ignoring abilities rather than maintenance in working memory circuits. |
| Dopaminergic medication normalizes aberrant causal signaling in frontoparietal-basal ganglia circuits associated with working memory in Parkinson's disease, impacting cognitive control mechanisms. |
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