Doses of sulphonylureas in diabetes
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Sulfonylureas are commonly used in the treatment of type 2 diabetes. The dosing of sulfonylureas varies depending on the specific agent used. Glimepiride, for example, is often prescribed at a low dose of ≤2 mg/day for adequate glycemic control . Different generations of sulfonylureas exist, with the first and second generations having class effects that include weight gain, allergic reactions, and hypoglycemia . In cases of sulfonylurea-induced hypoglycemia, octreotide has been used effectively in both pediatric and adult patients, with dosing recommendations ranging from 1-1.5 μg/kg in children to 50 μg in adults, followed by additional doses every 6 hours as needed . The ongoing debate surrounding the role of sulfonylureas in modern clinical practice emphasizes the importance of considering newer agents with potentially lower rates of hypoglycemia and secondary failure .
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| Papers (5) | Insight |
|---|---|
| The paper does not specify doses of sulfonylureas in diabetes. | |
| Not addressed in the paper. | |
| High-dose sulphonylurea treatment in diabetes patients with renal impairment should be approached cautiously due to increased risk of hypoglycaemia, especially with long-acting sulphonylureas. | |
| Sulfonylureas like glimepiride are used in small doses (e.g., ≤2 mg/day) for type 2 diabetes, with effectiveness but potential safety concerns like hypoglycemia and weight gain. | |
| Sulfonylureas are used in diabetes to increase insulin secretion. Specific doses are not mentioned in the paper, but they can induce hypoglycemia of varying severity. |
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