How are nanoparticles used to deliver drugs?
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Nanoparticles are used as drug delivery systems to improve the effectiveness and administration of various pharmaceutical complexes. They can overcome biological barriers and enhance intracellular penetration, control drug release, and improve bioavailability to targeted sites or organs . Lipid and polymer nanoparticles are commonly used for the clinical translation of genetic drugs, as they can facilitate the intracellular delivery of nucleic acids to the correct cells of the target organ using passive, active, and endogenous targeting mechanisms . Solid-lipid nanoparticles (SLNs) are another type of nanoparticle used to deliver medicine with better efficiency and bioavailability. SLNs can load lipophilic, hydrophilic, and hydrophobic drugs, enhancing their stability and target specificity . Nanoparticles can be organic (liposomes, micelles, dendrimers, polymer-based) or inorganic (gold, silica, carbon nanotubes, quantum dots), and have been extensively studied in various diseases, especially cancer. Some nanoparticle-based delivery systems are already approved by the FDA for drugs like Taxol, Carboplatin, and Cerubidine . Nanoparticles can also be designed to respond to specific stimuli, such as enzymes, pH, or light, further improving drug delivery .
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| Papers (5) | Insight |
|---|---|
| The paper discusses how lipid and polymer nanoparticles are used to deliver genetic drugs by circumnavigating biological barriers and facilitating intracellular delivery of nucleic acids in target organs. | |
| Nanoparticles can be designed to respond to stimuli such as enzymes, pH, glutathione, light, temperature, and ultrasound, allowing for targeted drug delivery. | |
| Nanoparticles are used as drug-delivery systems to improve intracellular penetration, control drug release, and enhance bioavailability to targeted sites or organs. | |
| The paper discusses how solid-lipid nanoparticles (SLNs) are used to deliver drugs. SLNs can load lipophilic, hydrophilic, and hydrophobic drugs to enhance their stability and bioavailability. | |
| Nanoparticles are used to deliver drugs by overcoming biological barriers and providing targeted drug delivery. They can be organic (liposomes, micelles, dendrimers) or inorganic (gold, silica, carbon nanotubes, quantum dots). |
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