How can i detect phage defecne systems?
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Phage defense systems can be detected using computational approaches based on genomic co-location within defense islands . These approaches identify conserved defense systems that are carried in specific locations or hotspots, typically within intact prophages and mobile genetic elements . Additionally, diverse phage-host interaction signals (PHISs) can be utilized to predict phage-host interactions and identify defense systems. These PHISs include sequence composition, CRISPR targeting, prophage, and protein-protein interaction signals . Machine-learning models based on PHIS features can be used to score the probability of phage-host interactions and predict these interactions . Therefore, by analyzing genomic co-location, PHISs, and utilizing machine-learning models, it is possible to detect and predict phage defense systems .
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| The paper does not provide information on how to detect phage defense systems. | |
142 Citations | The paper does not provide information on how to detect phage defense systems. |
| Phage defense systems can be detected using tools like CRISPRFinder, PILER-CR, and Seq2CRISPR to identify CRISPR spacers and protospacer targets. | |
| Phage defence systems can be detected using an experimental selection scheme that is agnostic to genomic context. |
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