How cell cycle is effected in PML-RARA acute promyelocytic leukemia?
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The cell cycle in PML-RARA acute promyelocytic leukemia is affected by several factors. Treatment with all-trans retinoic acid (ATRA) leads to the degradation of PML-RARA protein, allowing for differentiation of APL cells . The PML-RARA fusion protein, which is generated by the t(15;17) translocation, blocks differentiation in APL cells . Inhibition of the proteasome prevents the degradation of PML-RARA, suggesting that ATRA accelerates the degradation of PML-RARA through the proteasome pathway . Additionally, PML-RARA disrupts the normal subcellular localization of PML protein, which is involved in multiple cellular functions, including DNA damage response and homologous recombinational repair (HRR) . The disruption of PML-NB structure by PML-RARA fusion proteins reduces HRR, potentially contributing to genomic instability in APL . The effect of ATRA on PML-RARA-positive leukemic stem cells, which maintain the blast population and are the source of relapse, is still unclear .
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| Papers (3) | Insight |
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1 Citations | The effect of the PML-RARA fusion protein on the cell cycle in acute promyelocytic leukemia is not mentioned in the provided information. |
38 Citations | The PML-RARA fusion protein disrupts the normal cell cycle regulation in acute promyelocytic leukemia, leading to abnormal proliferation of promyelocytes. |
Open access•Journal Article | The effect of PML-RARA on the cell cycle in acute promyelocytic leukemia is not mentioned in the provided information. |
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