How do skin be a physical barrier ?
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The skin acts as a physical barrier by preventing the invasion of pathogens, fending off chemical assaults, and regulating the loss of water and solutes . The main components of the physical barrier are the stratum corneum, which consists of protein-enriched cells and lipid-enriched intercellular domains . The nucleated epidermis also contributes to the barrier through various junctions and cytoskeletal elements . Lipids are synthesized in the keratinocytes and form extracellular lipid-enriched layers, contributing to the barrier function . The cornified cell envelope, a protein/lipid structure, and ceramides A and B play a crucial role in barrier formation . Barrier function is regulated by cytokines, cyclic adenosine monophosphate, and calcium . Changes in epidermal differentiation and lipid composition can lead to a disturbed skin barrier, allowing the entry of allergens and causing inflammation in various skin conditions . The skin's physical barrier is also supported by biochemical properties and the microbiota, which make it difficult for microorganisms to survive and penetrate the body .
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01 Jan 2001 9 Citations | The skin acts as a physical barrier by having a layer called the stratum corneum, which is made up of keratinocytes and provides protection against water permeability, penetration of substances, and invasion by microbes and parasites. |
| The skin acts as a physical barrier by forming a protective layer called the stratum corneum, which consists of protein-enriched cells and lipid-enriched intercellular domains. This barrier prevents the invasion of pathogens and the unregulated loss of water and solutes. | |
| The skin acts as a physical barrier against infections due to its multiple cell layers, including an acellular horny layer, which makes it difficult for microorganisms to penetrate. | |
| The skin forms a physical barrier through components such as protein-enriched cells, lipid-enriched intercellular domains, and tight junctions, preventing the invasion of pathogens and the loss of water and solutes. | |
| The skin acts as a physical barrier by forming a protective layer between the body and the external environment, preventing the entry of harmful substances and pathogens. |
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