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How do the different structures of proteins affect their function?

Structural Classification of Proteins database

Protein secondary structure

Structural bioinformatics

Protein primary structure

Threading (protein sequence)

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Proteins have different structures, including primary, secondary, tertiary, and quaternary structures, which all play a role in their function . The primary structure refers to the linear chain of amino acids, while the secondary structure is stabilized by hydrogen bonds between atoms in the polypeptide backbone. The tertiary structure is the three-dimensional shape of the protein, determined by interactions between the side chains. Some proteins also have a quaternary structure, which involves the association of multiple polypeptides . The different structures of proteins are crucial for their specific functions. While proteins with similar global structures may not have the same function, proteins with similar local structural information tend to bind to similar types of molecular targets . Additionally, the diverse shapes of proteins allow them to perform a wide range of activities, from chemical catalysis to cell structure organization . The relationship between protein structure and function is complex and influenced by factors such as protein-protein interactions, posttranslational modifications, and cellular environment .

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Open access Biochemistry, Secondary Protein Structure Ibraheem Rehman, Mustafa Farooq, Salomé Calado Botelho - Show less +2 more 18 Dec 2020 5 Citations	The paper does not provide information on how the different structures of proteins affect their function.
Book Chapter•DOI Manoeuvring protein functions and functional levels by structural excursions Vasam Manjveekar Prabantu, Arangasamy Yazhini, Narayanaswamy Srinivasan - Show less +2 more 01 Jan 2020 4 Citations	The paper discusses how three-dimensional structural features of proteins influence their functions in a cellular context. It highlights the implications of factors such as protein-protein interactions, interactions among domains within a multidomain protein, posttranslational modifications, and synonymous codon substitutions on protein functions.
Book Chapter•DOI Protein Structure and Function Herbert J. Fromm, Mark S. Hargrove - Show less +1 more 01 Jan 2012	The paper does not provide a direct answer to the query. The paper discusses the relationship between protein structure and function, but does not specifically explain how different protein structures affect their function.
Book Chapter•DOI Three-dimensional structure of proteins and disorders of protein misfolding 01 Jan 2023	The paper does not provide a direct answer to the query. The paper discusses the different hierarchical structures of proteins (primary, secondary, tertiary, and quaternary) but does not explicitly explain how these structures affect protein function.
Journal Article•DOI Understand protein functions by comparing the similarity of local structural environments Jiawen Chen, Zhong-Ru Xie, Yinghao Wu - Show less +2 more 01 Feb 2017-Biochimica et Biophysica Acta 7 Citations	The paper suggests that the function of a protein is not solely determined by its global structure, but rather by the similarity of its local structural environments.

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