How does chronic sleep deprivation in juvenile rats affect behavioral and psychiatric outcomes in adulthood?s?
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Chronic sleep deprivation during juvenile stages can have lasting effects on behavioral and psychiatric outcomes in adulthood. Studies show that sleep restriction in young rats leads to increased anxiety-like behavior, altered noradrenaline and serotonin levels in specific brain regions . Furthermore, chronic sleep deprivation induces similar anxiety-like behaviors in both juvenile and young adult mice, affecting body weight and synaptic protein levels differently between the two age groups . Additionally, sleep disruption in adolescents can result in a hyperdopaminergic state, altered neuronal activity, and increased sensitivity to environmental stimuli, potentially contributing to the development of psychiatric disorders . These findings highlight the critical impact of chronic sleep deprivation during early stages of life on long-term behavioral and psychiatric outcomes in adulthood.
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| Chronic sleep deprivation in juvenile rats can lead to depressive- and anxiety-like behaviors in adulthood. Modulation of the melatonin receptor pathway and brain lipidome may offer therapeutic benefits. | |
| Chronic sleep deprivation in juvenile rats induces hyperdopaminergic status, altered neuronal activity, and increased corticotrophin-releasing factor signaling, potentially leading to behavioral and psychiatric abnormalities in adulthood. | |
| Chronic sleep deprivation in juvenile rats leads to impaired hippocampal synaptic plasticity and depressive-like behaviors in adulthood, which can be mitigated by venlafaxine and melatonin treatment. | |
| Chronic sleep deprivation in juvenile rats leads to increased anxiety-like behavior in adulthood, along with alterations in noradrenaline, serotonin, and dopamine levels in specific brain regions. | |
1 Citations | Chronic sleep deprivation in juvenile mice leads to similar anxiety-like behaviors in adulthood, with differing molecular changes in synaptic proteins, impacting physical and cognitive development. |
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