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How does the consumption of licorice affect fertility and sperm count in both men and women?

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Consumption of licorice, specifically its key component glycyrrhizin, can impact fertility and sperm count in both men and women. Glycyrrhizin, found in licorice, can induce apparent mineralocorticoid excess syndrome through inhibition of 11β-hydroxysteroid dehydrogenase type 2, leading to hypertension and fluid retention . In women, licorice extracts containing high levels of glycyrrhizic acid have been linked to hypokalemia, potentially affecting fertility . Additionally, glycyrrhizin can suppress 11-hydroxysteroid dehydrogenase, causing hypermineralocorticoid-like effects, which may impact fertility in both rodents and humans . However, a phase 1 clinical study showed that a standardized licorice extract did not cause significant pharmacokinetic interactions affecting fertility-related enzymes in menopausal and postmenopausal women .

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Journal Article•DOI Pharmacokinetic Interactions of a Licorice Dietary Supplement with Cytochrome P450 Enzymes in Female Participants Jialin Liu, Suzanne Banuvar, Marlos A. G. Viana, Elena Barengolts, Shao-Nong Chen, Guido F. Pauli, Richard B. van Breemen - Show less +6 more 03 Nov 2022-Drug Metabolism and Disposition	Not addressed in the paper.
Open access•Journal Article•DOI Licorice consumption causing severe hypokalemia-induced paresis Luca Bettini, Thibault Parent, Jacques Serratrice - Show less +2 more 01 Jan 2022-Medicine, case reports and study protocols	Not addressed in the paper.
Book Chapter•DOI Glycyrrhizic Acid Shafiya Rafiq, Summira Rafiq, Priyanka Suthar, Gulzar Ahmad Nayik, Harish Kumar - Show less +4 more 10 Feb 2022	Consumption of licorice, specifically glycyrrhizin, does not directly impact fertility or sperm count according to the paper. It mainly affects cortisol levels and has medicinal properties.
Journal Article•DOI [Adverse effects of licorice consumed as food: An update]. Weniko Caré, Guillaume Grenet, Céline Schmitt, Sedogo P. Michel, Jérôme Langrand, G. L. le Roux, Dominique Vodovar - Show less +6 more 31 Mar 2023-Revue de Médecine Interne	Not addressed in the paper.

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Does licorice root lower testosteron levels?4 answersLicorice root has been shown to lower testosterone levels in several studies ^[Josephs et al.]. The active component in licorice, glycyrrhizic acid, interferes with enzymes involved in testosterone production, such as 17β-hydroxysteroid dehydrogenase and 11-β-hydroxysteroid dehydrogenase ^[Blanpain] ^[Armanini et al.] ^[Fukui et al.]. This interference leads to a decrease in serum testosterone concentration ^[Josephs et al.] ^[Armanini et al.]. Licorice consumption has been associated with apparent mineralocorticoid excess (AME) due to its mineralocorticoid-like activity ^[Blanpain]. Excessive consumption of licorice can cause sodium retention, potassium excretion, and potential cardiovascular complications ^[Blanpain]. Licorice has also been suggested as an adjuvant therapy for hirsutism and polycystic ovary syndrome due to its ability to reduce testosterone levels ^[Armanini et al.]. In conclusion, licorice root can lower testosterone levels through its effects on testosterone production enzymes, and its consumption should be monitored to avoid potential side effects ^[Josephs et al.] ^[Blanpain] ^[Armanini et al.] ^[Fukui et al.].

What are the mechanisms by which a libido and fertility drink may affect the lipid profile of men?5 answersA libido and fertility drink may affect the lipid profile of men through various mechanisms. One possible mechanism is the use of Lingzhi mushroom, cassia seed, kudzuvine root, buckwheat tea, celery, honey, corn, and purified water in the drink, which are all efficient in lowering blood lipid levels and softening blood vessels. Another mechanism could be the consumption of alcohol, which has been found to have differential effects on lipid measures depending on the amount of alcohol intake. Heavy alcohol consumption is negatively associated with the risk of low high-density lipoprotein cholesterol (HDL-C) but increases the risk of high triglycerides. Additionally, exercise has been proposed as a strategy to improve blood lipids, and it may play a role in the effects of the drink on lipid profiles. However, further research is needed to fully understand the specific mechanisms by which the libido and fertility drink affects the lipid profile of men.

What are the effects of Libido and fertility drink on lipid profile in men?5 answersLibido, a commercial product derived from fertilized chicken eggs, has been found to have a significant enhancing effect on sexual desire in men with normal and reduced sexual drive. It has been shown to improve sexual desire in as little as 2 weeks of use, with 58% of participants reporting improvement in low sexual desire. Additionally, Libido has been reported to have significant effects on the frequency of sexual intercourse, increased self-esteem, level of happiness, and stamina. However, there is no information available in the provided abstracts regarding the effects of Libido or a fertility drink on lipid profile in men.

Do cannabinoids have any effect on the fertility of humans or animals?3 answersCannabinoids, including both exogenous and endogenous cannabinoids, have been shown to have effects on fertility in both humans and animals. In females, cannabinoids can affect various aspects of reproductive function, including sexual desire and receptivity, folliculogenesis, ovulation, and oviductal transport. In males, cannabinoids can impact testicular morphology, sperm parameters, and male reproductive hormones, leading to reduced fertility. However, the exact effects of cannabinoids on fertility are still not fully understood, and more research is needed to determine the mechanisms and reversibility of these effects. It is important to note that most of the evidence available is from pre-clinical studies, and further well-controlled studies are required to evaluate the effects of cannabinoids on fertility in both humans and animals.

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