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How does the use of artificial placenta affect the survival rates and development of preterm infants?

Centrifugal pump

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The utilization of artificial placenta systems has shown promising outcomes in enhancing the survival rates and development of preterm infants . These systems aim to replicate the physiological environment of the placenta, providing extracorporeal gas exchange and supporting normal lung growth outside the uterus. Research has demonstrated that artificial placenta models have led to increased survival times, stable hemodynamics, successful organ maturation, and normal neurological development in experimental animal models. Additionally, advancements in artificial placenta technology have shown potential in preventing lung injuries, maintaining lung development, and reducing the risk of neurological disabilities in preterm infants. However, challenges such as optimizing circuit design, preventing infection, and addressing nutritional needs remain to be resolved before widespread clinical implementation.

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Open access•Journal Article•DOI Impact of the Addition of a Centrifugal Pump in a Preterm Miniature Pig Model of the Artificial Placenta Alex J Charest-Pekeski, Steven K. S. Cho, Tanroop Aujla, Liqun Sun, Alejandro A. Floh, Mark J. McVey, A Sheta, Marvin Estrada, Lynn Crawford-Lean, Celeste Foreman, Dariusz Mroczek, Jaques Belik, Brahmdeep S. Saini, Jessie Mei Lim, Olivia Moir, Fu-Tsuen Lee, Megan Quinn, Jack R. T. Darby, Mike Seed, Janna L. Morrison, Christoph Haller - Show less +20 more 22 Jul 2022-Frontiers in Physiology 2 Citations	The addition of a centrifugal pump in an artificial placenta system improves survival in preterm pigs by enhancing umbilical vein flow and reducing right ventricular afterload, yet heart failure still develops.
Open access•Journal Article•DOI Artificial womb: a paradigm shift for saving extremely premature infants Iain Sheridan 01 Jun 2023-Chinese Medical Journal	Not addressed in the paper.
Open access•Book Chapter•DOI Advancing Medical Frontiers: Unveiling the Potential of Artificial Placenta in Perinatal Medicine 21 Jun 2023	Artificial placenta systems improve survival rates and organ maturation in preterm infants by mimicking fetal physiology, enhancing stability, and offering potential solutions to respiratory challenges.
Open access•Posted Content•DOI A Rigid Parallel-Plate Artificial Placenta Oxygenator with a Hemocompatible Blood Flow Path David G. Blauvelt, Nicholas Higgins, Bianca De, Mark S. Goodin, Nathan Wright, Charles A. Blaha, Jarrett Moyer, Benjamin W. Chui, Francisco Baltazar, Peter Oishi, Shuvo Roy - Show less +10 more 31 May 2023-bioRxiv	The use of a rigid flat-plate artificial placenta oxygenator may improve survival rates and lung development in preterm infants by providing extracorporeal gas exchange outside the uterus.
Open access•Journal Article•DOI Background, Physiology and Ethics of Artificial Placentas Ashley Zubkowski 07 Jul 2023-Spectrum	The use of artificial placenta aims to minimize physiological stress in preterm infants, potentially improving survival rates and development by creating a more natural environment.

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