How does transcriptomics enable the study of limb regeneration in the plethodontid salamander (Bolitoglossa ramosi)?
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Transcriptomics enables the study of limb regeneration in the plethodontid salamander (Bolitoglossa ramosi) by providing insights into the molecular mechanisms involved in tissue regeneration. Through bioinformatic approaches, the Ramosin peptide was identified from the de novo assembled transcriptome of Bolitoglossa ramosi . This peptide exhibited antimicrobial activity against Gram-positive and Gram-negative bacteria without any hemolytic activity . Additionally, single-cell RNAseq analysis identified Tig1/Rarres1 as a potential determinant of proximal identity in salamander limb regeneration . Tig1 encodes a cell surface molecule that regulates the expression of genes along the proximo-distal axis of the limb and influences cell surface interactions . Furthermore, the sequencing of the axolotl genome provides a blueprint to mine regeneration insights from other salamander species, including plethodontid salamanders . By studying the transcriptome of different salamander species, shared and unique mechanisms of regeneration can be revealed, contributing to a better understanding of the evolutionary history of salamander limb regeneration .
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| Papers (5) | Insight |
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| The provided paper does not mention anything about the plethodontid salamander (Bolitoglossa ramosi) or how transcriptomics enables the study of limb regeneration in this species. The paper focuses on the Asian tree frog Polypedates maculatus and its limb regeneration mechanisms. | |
22 Citations | The provided paper does not mention the plethodontid salamander (Bolitoglossa ramosi) or how transcriptomics enables the study of limb regeneration in this species. |
6 Citations | The provided paper does not specifically mention the study of limb regeneration in Bolitoglossa ramosi or how transcriptomics enables this study. |
| Transcriptomics enables the study of limb regeneration in Bolitoglossa ramosi by identifying candidate peptides through alignments with the Fasta36 tool between the salamander's transcriptome and peptides reported in various databases. | |
| The provided paper does not mention the plethodontid salamander (Bolitoglossa ramosi) or how transcriptomics enables the study of limb regeneration in this species. |
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