How mtDNA haplogroups correlates with cardiomyopathy?
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Mitochondrial DNA (mtDNA) haplogroups play a significant role in cardiomyopathy. Research indicates that specific mtDNA haplotypes can influence mitochondrial structure, function, and reactive oxygen species levels in cardiomyocytes, impacting cardiomyopathy development and progression . Studies have explored the association between common European mtDNA haplogroups and cardiometabolic risk factors, revealing subtle differences in risk factor trajectories . Furthermore, investigations have shown that the distribution of mtDNA haplogroup subhaplogroups differs between hypertrophic cardiomyopathy (HCM) patients and controls, suggesting a potential link to disease susceptibility . Additionally, cases of mitochondrial cardiomyopathy with specific mtDNA mutations exhibit varying clinical manifestations and histological findings, highlighting the role of mtDNA in disease severity and progression . Understanding these correlations can provide insights into the genetic modifiers of cardiomyopathy and potential treatment avenues .
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| Papers (4) | Insight |
|---|---|
8 Citations | Mitochondrial DNA haplogroups may contain gene modifiers influencing cardiomyopathy progression, as seen in specific population haplogroups with novel mtDNA variants potentially affecting disease outcomes. |
2 Citations | Mitochondrial DNA haplogroup H shows subtle differences in distribution between hypertrophic cardiomyopathy (HCM) cases and controls, suggesting a potential correlation with HCM susceptibility. |
| Not addressed in the paper. | |
| Mitochondrial haplotype influences cardiomyocyte mitochondrial structure and gene expression response to volume overload, with C3Hmt showing protective effects compared to C57mt in cardiomyopathy. |
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