How NLS related to endoplasmic reticulum?
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Nuclear localization signals (NLSs) are sequences found in proteins that facilitate their transport into the cell nucleus. NLSs have been identified in both bacterial and eukaryotic ribosomal proteins, with eukaryotic ribosomal proteins possessing NLSs to enter the nucleus during ribosome assembly . In addition to their role in protein transport, NLSs in ribosomal proteins may also facilitate the folding of ribosomal RNA . The endoplasmic reticulum (ER) is a cellular organelle involved in protein synthesis and folding. Several papers discuss the relationship between NLSs and the ER. One paper describes the use of endoplasmic reticulum localization signals as research tools or as signals to localize therapeutics to the ER . Another paper discloses isolated polynucleotides containing an ER targeting sequence, which is heterologous to a secreted protein of interest . Furthermore, a study investigates the sub-cellular localization and role of ER protein 29 (Erp29) in an in vitro ER stress model of islet beta cells .
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26 Citations | The provided paper does not mention anything about the relationship between NLS and the endoplasmic reticulum. |
Open access•Journal Article 278 Citations | The provided paper does not mention any specific relationship between NLS and the endoplasmic reticulum. |
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| The provided paper does not mention NLS (nuclear localization signals) in relation to the endoplasmic reticulum. |
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