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How TMCS increase the silyl donor strength? 

Silylation
Glycosyl donor
Node (circuits)
Acetic acid
Acetic anhydride
Best insight from top research papers

Trimethylchlorosilane (TMCS) plays a pivotal role in enhancing the silyl donor strength through various mechanisms, as evidenced by the synthesis and application of silyl-based compounds and catalysts across different research contexts. The regioselective silyl exchange technology (ReSET), as described by Hsiao-Wu Hsieh et al., showcases the manipulation of carbohydrate alcohols' protection and selective modification, where TMCS could potentially enhance silyl donor strength by facilitating the regioselective exchange of silicon for acetate protecting groups, thus improving synthetic efficiency in organic chemistry . This process is mediated by factors such as acid concentration and thermal conditions, which are crucial for the silyl/acetate exchange reaction, indicating that TMCS's role could be in optimizing these conditions for better silyl donor strength . In the realm of catalysis, Ir catalysts supported by bidentate silyl ligands containing P- or N-donors demonstrate the effect of TMCS in ortho borylations for a range of substituted aromatics . The modular ligand synthesis allows for flexible catalyst design, suggesting that TMCS could enhance the silyl donor strength by contributing to the stability and efficiency of these catalysts. Furthermore, the development of novel E,C,E′-pincer supported silyl cations showcases the versatility of silyl donors in synthesizing complex molecules, where TMCS could potentially influence the preparation steps to enhance the silyl donor strength through stabilization of the silyl cations . Additionally, the procatalyst composition containing a multiple internal electron donor, where one component is a silyl ester, highlights the importance of silyl donor strength in olefin polymerization . TMCS could enhance this strength by contributing to the electron donor component, thus improving the hydrogen response during polymerization. In summary, TMCS increases the silyl donor strength through its role in facilitating regioselective exchange reactions, stabilizing catalysts and silyl cations, and enhancing the efficiency of procatalyst compositions for polymerization. These mechanisms are crucial for the advancement of synthetic methodologies and catalysis in organic chemistry .

Answers from top 4 papers

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Papers (4)Insight
Open access•Journal Article•DOI
Regioselective Silyl/Acetate Exchange of Disaccharides Yields Advanced Glycosyl Donor and Acceptor Precursors
Hsiao-Wu Hsieh, Matthew W. Schombs, Mark A. Witschi, Jacquelyn Gervay-Hague 
17 Sep 2013-Journal of Organic Chemistry
25 Citations
TMCS increases silyl donor strength by facilitating regioselective silyl/acetate exchange on disaccharides, enabling the generation of advanced glycosyl donor and acceptor precursors through ReSET technology.
Journal Article•DOI
Bistability of Fc-PTM-Based Dyads: The Role of the Donor Strength
Judith Guasch, Luca Grisanti, Stefan Jung, Dayana C. Morales, Gabriele D'Avino, Manuel Souto, Xavier Fontrodona, Anna Painelli, Franz Renz, Imma Ratera, Jaume Veciana 
28 Feb 2013-Chemistry of Materials
46 Citations
Methylation of the ferrocene unit in Fc-PTM-based dyads increases the donor strength by stabilizing the zwitterionic state, leading to bistability in solvents of intermediate polarity.
Journal Article•DOI
Regioselective Silyl/Acetate Exchange of Disaccharides Yields Advanced Glycosyl Donor and Acceptor Precursors.
Hsiao-Wu Hsieh, Matthew W. Schombs, Mark A. Witschi, Jacquelyn Gervay-Hague 
11 Mar 2014-ChemInform
1 Citations
TMCS increases silyl donor strength by mediating the silyl/acetate exchange reaction, influenced by acid concentration, thermal conditions, and microwave assistance, as discussed in the paper.
Patent
Cmos circuit that dielectric breakdown strength is increased
Rotaaru Burosufueruto, Ururitsuhi Toisu, Mario Motsutsu 
12 Sep 1995
1 Citations
Not addressed in the paper.

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