How to describe antibacterial activity?
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Antibacterial activity can be described based on various chemical compounds' effectiveness against bacterial strains. Different studies have explored this by evaluating minimum inhibitory concentrations (MICs) of compounds against both Gram-positive and Gram-negative bacteria. Research has shown that the antibacterial activity of compounds can be influenced by factors such as molecular descriptors, global reactivity, and the number of quaternary ammonium groups present in the compound. Additionally, the mechanism of interaction with bacterial membranes and the impact on bacterial respiration have been studied to understand the antibacterial effects. Utilizing quantum chemical, topographic, and topological indices can aid in predicting and classifying the antibacterial activity of compounds accurately. .
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| Papers (5) | Insight |
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| Antibacterial activity is described using a combination of piecewise linear regression-discriminant analysis, quantum chemical, topographic, and topological descriptors to predict biological activity values of furylethylenes. | |
16 Citations | The antibacterial activity involves polymer-supported multiquaternary ammonium salts penetrating bacterial cells, disrupting membranes, inhibiting functions, and causing cell death through cytoplasmic membrane interaction and degradation processes. |
2 Citations | Antibacterial activity is assessed by minimum inhibitory concentrations (MICs) against specific bacteria strains, with electrophilic potency, molecular weight, and other molecular descriptors influencing effectiveness. |
| Antibacterial activity can be described by evaluating the effectiveness of newly synthesized unsymmetrical sulfamides against bacterial strains through disc diffusion and MIC methods, influenced by their chemical structure. | |
| Antibacterial activity is evaluated in vitro using minimum inhibitory concentration (MIC) values. Isoxazole derivatives showed mild antibacterial activity, with compounds 3d and 4d being the most active. |
Related Questions
How activity antimicrobial from plant?5 answersPlant extracts exhibit antimicrobial activity through various mechanisms. Studies have shown that extracts from medicinal plants like Arctostaphylos uva-ursi, Potentilla erecta, Symphytum officinale, and Geranium possess significant antibacterial properties against pathogens like Staphylococcus aureus and Escherichia coli. Essential oils from plants like C. pluriglandulosus have demonstrated antimicrobial potential against human pathogenic yeasts, with mechanisms involving cell membrane damage, ROS overproduction, and induction of apoptosis in microorganisms. Additionally, bacterial cellulose modified with plant extracts such as rosella petals has shown enhanced antibacterial activity against Pseudomonas aeruginosa, attributed to changes in functional groups and fibrillar network structure. Furthermore, plant extracts like Gambooge, Clove, Marjoram, and others have been found to inhibit various standard microbial strains, showcasing their antimicrobial efficacy against foodborne pathogens and spoilage microorganisms.
What are the phytochemicals responsible for antibacterial activity of a plant?3 answersPhytochemicals responsible for the antibacterial activity of plants include flavonoids, polyphenols, alkaloids, terpenes, cannabinoids, xanthones, and fatty acids. These compounds have been found to exhibit antimicrobial effects against various bacteria, including Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, and Bacillus sp.. The antibacterial activity of phytochemicals is attributed to their ability to destroy the membrane structure of bacteria and inhibit efflux pumps. Some phytochemicals have also shown synergistic effects when combined with antibiotics, enhancing their antibacterial activity. Examples of phytochemicals with significant antibacterial activity include rubraxanthone, parvixanthone G, cowanin, garcihombronane B, and garcihombronane C. Further research is needed to explore the potential of these phytochemicals as natural food preservatives and to prevent the emergence of bacterial resistance.
Is collagen is antibacterial?5 answersCollagen has been shown to have antibacterial properties. Collagen-based nanocomposite dressings have been developed with broad-spectrum antibacterial activity to promote infected wound healing. Streptococcal bacterial collagen, secreted on the surface of Streptococcus pyogenes, has been used as a template for nucleating inorganic particles, including hydroxyapatite crystals, silver nanoparticles, and silica nanoparticles. Collagen/mineral composites formed using bacterial collagen show an even distribution of inorganic particles and have a more homogeneous size compared to minerals formed without the collagen scaffold. Collagen composite membranes loaded with minocycline have demonstrated sustained antibacterial effects against Staphylococcus aureus. Additionally, collagen nanosheets modified with an antibacterial peptide have shown high antibacterial activity. Overall, these findings suggest that collagen and collagen-based materials have antibacterial properties and can be used in wound healing and tissue engineering applications.
What is antimicrobial activity in foods?5 answersAntimicrobial activity in foods refers to the ability of certain compounds to inhibit the growth or kill microorganisms present in food. These compounds can be naturally occurring or synthetically derived antimicrobials. They are added to foods, food packaging, food contact surfaces, or food processing environments to enhance the quality and safety of food. The antimicrobial activity of foods can vary depending on the type of food and the specific microorganisms targeted. For example, caffeine has been found to inhibit bacteria at certain concentrations. Orange juice, honey, and yoghurt have also been shown to have antimicrobial activity against bacterial pathogens and spoilage agents. Understanding the mechanisms of antimicrobial activity in foods is important for predicting the effectiveness of antimicrobials in different food systems and for developing strategies to preserve food quality and safety.
How can the antibacterial activity of antibiotics be evaluated in vitro?5 answersThe antibacterial activity of antibiotics can be evaluated in vitro using various methods. One common method is the disc diffusion method, where a paper disc containing a specific concentration of the antibiotic is placed on an agar plate inoculated with the bacteria of interest. The antibiotic diffuses into the agar, creating a concentration gradient, and the zone of inhibition around the disc indicates the effectiveness of the antibiotic in inhibiting bacterial growth. Another method is the agar dilution method, where the antibiotic is incorporated into the agar at different concentrations. The minimum inhibitory concentration (MIC) is determined as the lowest concentration of the antibiotic that inhibits visible bacterial growth. The minimum bactericidal concentration (MBC) can also be determined by sub-culturing the contents of the MIC onto growth medium and determining the concentration at which no bacterial growth is observed. These methods provide valuable information about the potency and effectiveness of antibiotics against specific bacterial strains.
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