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How to measure impact of personalized therapies ?

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Personalized therapies can be measured in terms of their impact by considering patient characteristics, therapeutics, and diagnostic testing to understand individual patient responses to treatment . This approach aims to improve the matching process between patients and treatments and enhance patients' understanding of the risk of serious side effects. The impact of personalized medicine depends on factors such as the number of treatments, the correlation between treatment effects, and the amount of noise in a patient's individual treatment effect signal . In the context of multiple sclerosis treatments, personalized medicine has the potential to increase the health impact of existing treatments by approximately 50% by informing patients of their individual treatment effect and risk of serious side effects . Therefore, measuring the impact of personalized therapies involves assessing the effectiveness of treatment matching and the communication of individual treatment effects and risks to patients.

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Open access•Journal Article•DOI The impact of personalised therapies on respiratory medicine. J. Stuart Elborn 01 Mar 2013-European Respiratory Review 9 Citations	The impact of personalized therapies can be measured by assessing improvements in clinically important outcomes such as spirometry, exacerbations, and symptom scores.
Proceedings Article•DOI Pharmacodynamics modeling based on in vitro 2D cell culture experiments Borbála Gergics, Balázs Gombos, Flora Vajda, András Füredi, Gergely Szakács, Daniel Andras Drexler - Show less +5 more 09 Oct 2022 1 Citations	The impact of personalized therapies can be measured by examining the effect of certain drugs on in vitro cell cultures and creating pharmacodynamics models.
Open access•Report•DOI Measuring the Potential Health Impact of Personalized Medicine: Evidence from MS Treatments Kristopher J. Hult 06 Oct 2017-Research Papers in Economics 6 Citations	The impact of personalized therapies can be measured by comparing the health outcomes of patients who receive personalized treatments with those who receive standard treatments.
Book Chapter•DOI Psychosocial Impact of Personalized Therapies in Oncology. Georgia Schilling, Frank Schulz-Kindermann - Show less +1 more 01 Jan 2018-Recent results in cancer research 3 Citations	The paper does not provide information on how to measure the impact of personalized therapies.

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What are the potential implications of these findings for the development of more effective and personalized cancer therapies?5 answersThe findings from the provided contexts suggest several implications for the development of more effective and personalized cancer therapies. Firstly, the concept of synthetic lethality presents a promising strategy for specific cancer cell targeting, as seen in the interaction of APC and GFER in colon cancer treatment. Additionally, leveraging germline pathogenic variants for personalized treatments in hereditary cancer syndromes has shown success with inhibitors tailored to specific genetic mutations. Molecular profiling technologies, including next-generation sequencing, enable the identification of genetic alterations for targeted therapies, leading to precision medicine in cancer care. Moreover, functional tumor profiling and single-cell drug profiling offer novel approaches for individualized treatment choices, potentially enhancing treatment outcomes in heterogeneous cancers. These insights collectively support the advancement of tailored and more effective cancer therapies.

How does the adoption of personalized medicine affect patient outcomes and healthcare costs?4 answersThe adoption of personalized medicine has the potential to improve patient outcomes and reduce healthcare costs. Personalized medicine focuses on developing individualized approaches to each patient's illness based on their genomic portfolio. By understanding a patient's genetic and epigenetic factors, medical therapy can be predicted and tailored to be safe and effective for specific individuals. This approach can lead to earlier disease diagnosis, including cancer, and the prevention of more invasive procedures, resulting in improved quality of life and reduced financial burdens for patients. Additionally, personalized medicine can help optimize the use of existing treatments, minimizing side effects and ensuring better results while being cost-effective. The incorporation of personalized medicine interventions into routine healthcare requires evaluation of their clinical effectiveness and economic cost, as well as reimbursement by payers and insurance bodies. Overall, personalized medicine has the potential to enhance patient well-being, longevity, and cost-effectiveness of healthcare.

How can epigenetics be used to personalize treatments?5 answersEpigenetics can be used to personalize treatments by examining individual patients' epigenetic profiles in conjunction with other indicators. Epigenetic changes, which are reversible and heritable changes in gene function, can capture the unique regulatory landscape and exposure to environmental stimuli of an individual. In the field of oncology, epigenetics contributes to molecularizing medicine by understanding the molecular processes involved in tumor progression. It also helps identify epigenetic mechanisms underlying the environmental causes of cancers, allowing for personalized assessments of patients' life paths. In the context of allogeneic hematopoietic stem cell transplantation (allo-HSCT), epigenetic compounds such as DNA demethylating agents and histone deacetylases inhibitors have shown promise in reducing complications, relapse risk, and graft versus host disease. Furthermore, epigenetic data can be used to provide personalized wellness recommendations, taking into account an individual's epigenetic profile and wellness goals.

How do surveys and questionnaires impact personalization of information?5 answersSurveys and questionnaires impact personalization of information in various ways. Personalization of information retrieval (PIR) aims to tailor searches towards individual users and user groups by considering additional information about users. In Internet-based surveys, personalization techniques such as using a personalized salutation or a personalized URL can affect disclosure of sensitive information. A personalized salutation tends to increase active non-disclosure, while a log-on procedure increases non-disclosure to sensitive questions. In mail surveys, personalization through cover letters with pictures of the researcher can have a negative effect on response rates, suggesting that repeated use of personalized mailings may hinder questionnaire returns. Personalization of email invitations in web surveys has been found to significantly increase response rates, but respondents in the personalization condition may exhibit more social desirability bias to sensitive questions. Overall, surveys and questionnaires can be influenced by personalization techniques, impacting response rates and data quality.

What is the importance of personalized therapy in cancer?3 answersPersonalized therapy in cancer is important because it takes into account the individual-level variability in genes, tumor characteristics, and lifestyle factors, allowing for a more targeted and effective treatment approach.This approach recognizes that each patient may respond differently to the same treatment regimen, even if they have the same type of cancer. By utilizing technologies such as metabolomics and next-generation sequencing, researchers can better understand the metabolic alterations and genetic mutations that contribute to cancer development, chemotherapy resistance, and clonal evolution.This knowledge can then be used to tailor therapy strategies to each patient's specific needs, increasing the likelihood of successful outcomes and reducing side effects. Additionally, incorporating the concept of chronotherapy, which considers an individual's circadian rhythm, and utilizing nanotechnology for targeted drug delivery, can further enhance the effectiveness and tolerability of personalized cancer treatment.Overall, personalized therapy holds promise for improving cancer treatment outcomes and advancing the field of oncology.

How can we measure the impact of research?5 answersMeasuring the impact of research can be done using various methods. One approach is to use bibliographic measures such as the number of citations received and the h-index. However, this method has limitations, including doubts about whether a citation truly reflects the impact of a paper and the potential for manipulation through unmerited references. Another solution is to use ArticleRank or the Transitive Research Impact Score (TRIS) to constrain the impact of a single publication on others. Additionally, the societal impact of research can be measured using qualitative tools like the Social Impact ex-post Evaluation Protocol (SIEP). Another tool, the MULTI-ACT Master Scorecard (MSC), allows for the collective assessment of research impact across multiple dimensions, including excellence, efficacy, economic, social, and patient-reported outcomes. Questionnaires can also be used to measure the perceived impacts of research projects, with metrics varying depending on the discipline and context.

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