G
Gergely Szakács
Researcher at Medical University of Vienna
Publications - 133
Citations - 10195
Gergely Szakács is an academic researcher from Medical University of Vienna. The author has contributed to research in topics: ATP-binding cassette transporter & P-glycoprotein. The author has an hindex of 38, co-authored 121 publications receiving 9174 citations. Previous affiliations of Gergely Szakács include National Institutes of Health & Government of the United States of America.
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Journal ArticleDOI
Targeting multidrug resistance in cancer
Gergely Szakács,Jill K. Paterson,Joseph A. Ludwig,Catherine Booth-Genthe,Michael M. Gottesman +4 more
TL;DR: Various approaches to combating multidrug-resistant cancer are described, including the development of drugs that engage, evade or exploit efflux by ABC transporters.
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Human Multidrug Resistance ABCB and ABCG Transporters: Participation in a Chemoimmunity Defense System
TL;DR: It is suggested that multidrug transporters are essential parts of an innate defense system, the "chemoimmunity" network, which has a number of features reminiscent of classical immunology.
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Predicting drug sensitivity and resistance: profiling ABC transporter genes in cancer cells
Gergely Szakács,Jean Philippe Annereau,Samir Lababidi,Uma Shankavaram,Angela Arciello,Kimberly J. Bussey,William C. Reinhold,Yanping Guo,Gary D. Kruh,Mark Reimers,John N. Weinstein,Michael M. Gottesman +11 more
TL;DR: This work profiled mRNA expression of the 48 known human ABC transporters in 60 diverse cancer cell lines used by the National Cancer Institute and found and validated compounds whose activity is potentiated, rather than antagonized, by the MDR1 multidrug transporter.
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The role of ABC transporters in drug absorption, distribution, metabolism, excretion and toxicity (ADME-Tox).
TL;DR: This review explores how human ABC transporters modulate the pharmacological effects of various drugs, and how this predictable ADME-TOX modulation can be used during the process of drug discovery and development.
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Functional characterization of the human multidrug transporter, ABCG2, expressed in insect cells.
Csilla Özvegy,Thomas Litman,Gergely Szakács,Zoltan Nagy,Susan E. Bates,András Váradi,Balázs Sarkadi +6 more
TL;DR: The expression of the ABCG2 protein in Sf9 insect cells resulted in a high-capacity, vanadate-sensitive ATPase activity in isolated membrane preparations, indicating that no additional partner protein is required for the activity of this multidrug transporter, probably working as a homodimer.