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Is antagonistic pleiotropy ubiquitous in aging biology?

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Antagonistic pleiotropy hypothesis

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Antagonistic pleiotropy, a concept where genes benefit early-life fitness but harm later-life survival, is a prevalent phenomenon in aging biology. Research indicates that antagonistic pleiotropy is common if not ubiquitous . While traditionally viewed as a constraint on adaptation, recent studies suggest that antagonistic pleiotropy may not always lead to maladaptive trade-offs . It has been theorized that this genetic mechanism evolved as a group-selected adaptation to balance fertility and longevity within populations, preventing overshoot and collapse . Despite some mutations leading to extended lifespan without apparent costs, the overall evidence supports the widespread presence of antagonistic pleiotropy in shaping the biology of aging.

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Open access•Posted Content•DOI What is Antagonistic Pleiotropy Josh Mitteldorf 15 May 2018-bioRxiv 22 Citations	Antagonistic pleiotropy is a dominant theory in aging biology, but not ubiquitous; mutations can lead to longer lifespan without apparent cost, challenging the theory's logic.
Open access•Journal Article•DOI Is antagonistic pleiotropy ubiquitous in aging biology Steven N. Austad, Jessica M. Hoffman - Show less +1 more 01 Jan 2018-Evolution, Medicine, and Public Health 102 Citations	Antagonistic pleiotropy is common, possibly ubiquitous in aging biology, supported by genetic evidence. It suggests genes enhancing early fitness may accelerate aging, impacting interventions for human health.
Open access•Journal Article•DOI What Is Antagonistic Pleiotropy Josh Mitteldorf 01 Dec 2019-Biochemistry 16 Citations	Antagonistic pleiotropy is not universal in aging biology; examples exist where mutations lead to longer lifespan without apparent costs, challenging the theory's ubiquity.
Open access•Journal Article•DOI Antagonistic pleiotropy for carbon use is rare in new mutations. Mrudula Sane, Joshua John Miranda, Deepa Agashe - Show less +2 more 13 Sep 2018-Evolution 30 Citations	Not addressed in the paper.
Open access•Posted Content•DOI Antagonistic Pleiotropy Is Unexpectedly Rare In New Mutations Mrudula Sane, Joshua John Miranda, Deepa Agashe - Show less +2 more 16 Apr 2018-bioRxiv 1 Citations	Not addressed in the paper.

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