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Is CBG bad for your lungs?

Voltage-dependent calcium channel

Calcium metabolism

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Open access•Journal Article•DOI Inhibitory effect of cinobufagin on L-type Ca2+ currents, contractility, and Ca2+ homeostasis of isolated adult rat ventricular myocytes. Pinya Li, Qiongtao Song, Tao Liu, Zhonglin Wu, Xi Chu, Xuan Zhang, Ying Zhang, Yonggang Gao, Jianping Zhang, Li Chu - Show less +9 more 25 May 2014-The Scientific World Journal 16 Citations	These findings contribute to the understanding of the cardioprotective efficacy of CBG.
Open access•Journal Article•DOI Free and Glucuronide Whole Blood Cannabinoids' Pharmacokinetics after Controlled Smoked, Vaporized, and Oral Cannabis Administration in Frequent and Occasional Cannabis Users: Identification of Recent Cannabis Intake. Matthew N. Newmeyer, Matthew N. Newmeyer, Madeleine J. Swortwood, Allan J. Barnes, Osama A. Abulseoud, Karl B. Scheidweiler, Marilyn A. Huestis, Marilyn A. Huestis - Show less +7 more 01 Dec 2016-Clinical Chemistry 121 Citations	CBG and CBN are recent-use cannabis markers after cannabis inhalation, but their absence does not exclude recent use.
Journal Article•DOI Characterization and quantification of corticosteroid-binding globulin in a southern toad, Bufo terrestris, exposed to coal-combustion-waste Chelsea K. Ward, Cristiano Fontes, Creagh W. Breuner, Mary T. Mendonça - Show less +3 more 15 May 2007-General and Comparative Endocrinology 12 Citations	This finding indicates that, in this species, CBG may not provide a protective mechanism during long-term pollution exposure.

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What is different LS-54 and Triton X-100?

LS-54 and Triton X-100 are distinct in their properties and applications. Triton X-100 is a non-ionic detergent known for its ability to reverse multidrug resistance (MDR) and solubilize proteins in various cell types. On the other hand, LS-54 is not specifically mentioned in the provided contexts. Triton X-100 has been reported to inhibit potassium channels at low concentrations and to affect L-type voltage-operated calcium channels, leading to relaxation of vascular smooth muscle cells. In liposome studies, Triton X-100 exhibited stronger effects compared to sodium dodecyl sulphate (SDS). Additionally, Triton X-100 has been utilized in the generation of uniform-sized vesicles using a layered liquid crystal system. Overall, Triton X-100's diverse applications and effects distinguish it from LS-54.What are yields of Bulel and Aucan Tritordeum?

The yield of 'Bulel' Tritordeum variety was observed to be 4753.5 kg ha-1 in response to fertilization in a field experiment in Greece. Additionally, Tritordeum, as a new cereal crop, has shown yields close to those of commercial wheats after only 12 years of breeding, indicating its potential as a viable crop option. On the other hand, the yield data for Aucan Tritordeum is not explicitly provided in the given contexts. However, the success of Tritordeum as a crop, in general, highlights its promising agronomic performance and potential as a genetic bridge for wheat breeding, showcasing its significance as a new and innovative crop. Further research and breeding efforts are ongoing to enhance the agronomic characteristics of Tritordeum varieties, indicating a positive trajectory for their future yields.Corrected calcium is different with calcium binding?

Corrected calcium levels are influenced by calcium binding, especially in conditions like multiple myeloma (MM) where paraproteins may bind calcium, affecting measurements. Studies show that in patients with MM, the correlation between corrected calcium and ionized calcium is weaker compared to control groups, indicating potential interference from calcium-binding paraproteins. Additionally, individual variations in calcium binding to albumin exist, making it necessary to use personalized regression coefficients for accurate correction of serum calcium levels. This variability in calcium binding affinity for albumin raises concerns about the accuracy of using average correction factors, highlighting the importance of considering individual factors in correcting calcium levels.What type of blood calcium examination?

Various methods are employed for examining blood calcium levels. These include potentiometry, flame photometry, mass spectrometry, and chromatography. While total calcium adjusted for protein or albumin concentration is commonly used, ionized calcium measurement is considered the reference test for diagnosing calcium disorders. Linearity surveys play a crucial role in evaluating the performance of clinical laboratories for blood calcium testing, with the majority of laboratories demonstrating good capability in this regard. A novel sequential injection analysis (SIA) system based on the arsenazo III method has been developed for the determination of total calcium in blood, offering a linear range and high precision in calcium detection. Additionally, a novel adaptation of the Bradford’s assay has been proposed for serum calcium level detection, enabling a cost-effective and user-friendly diagnostic approach.How using vitamin E will limit the effects of smoking on skin ?

Vitamin E plays a crucial role in mitigating the effects of smoking on the skin. Smoking exposes the skin to oxidants and free radicals, leading to increased lipid peroxidation. Vitamin E, a potent antioxidant, scavenges free radicals, protecting biological membranes from oxidative damage. Moreover, vitamin E, when topically applied, deactivates free radicals, shielding the skin from harmful effects of pollutants, chemicals, and UV rays. In smokers, supplementation with vitamin E has been shown to reduce lipid peroxidation, even when plasma concentrations are normal, indicating a conditioned insufficiency of vitamin E in smokers. By reducing oxidative stress and protecting against free radicals, vitamin E helps counteract the detrimental impact of smoking on skin health, making it a valuable component in skincare regimes for smokers.How CBD is absorbed in the gut review?

Cannabidiol (CBD) absorption in the gut is influenced by several factors, including the presence of food, the formulation of the CBD product, and the physiological and molecular mechanisms of the gastrointestinal (GI) tract. Studies have shown that the bioaccessibility of CBD significantly increases when consumed with food, particularly high-fat meals, which enhance its micellarization and absorption through the formation of micelles from hydrolyzed lipids. This is corroborated by clinical evidence suggesting that the absolute bioavailability of orally administered CBD under fasting conditions is approximately 6%, but can increase fourfold with a high-fat meal. The endocannabinoid system (ECS) in the GI tract, including the presence of cannabinoid receptors, endocannabinoids like anandamide and 2-arachidonylglycerol, and enzymes for endocannabinoid metabolism, plays a crucial role in the absorption and physiological effects of CBD. CBD's interaction with the ECS can modulate GI function, potentially benefiting conditions such as inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). Pharmacokinetic studies have highlighted the importance of formulation in CBD's bioavailability. Nanoemulsion preparations of CBD have demonstrated improved solubility and absorption compared to conventional oil formulations, irrespective of bile secretion, which is essential for the micelle formation necessary for the absorption of lipophilic substances like CBD. This suggests that advanced formulations can overcome some of the limitations of CBD absorption in the gut. Furthermore, the ECS's involvement in GI pathology and physiology, including its role in inflammation, motility, and secretion, underscores the therapeutic potential of targeting this system with cannabinoids for GI diseases. However, the variability in individual responses and the complexity of CBD's interactions with the ECS and GI tract highlight the need for further research to optimize CBD's therapeutic use and absorption in the gut.