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Anti-VEGF agents may represent new therapeutic alternatives for children with advanced disease.
Anti-VEGF-A therapies also have immunologic effects that may be used with a therapeutic goal in the future.
These results may implicate an additional therapeutic role for anti–VEGF-A when combined with chemotherapy.
In conclusion, we demonstrated a potential pharmacogenetic relationship between the VEGFA gene and treatment response to anti-VEGF therapy. The studies are registered at ClinicalTrials. gov under the identifiers NCT00474695 (http://clinicaltrials.