Is minocycline effect in glioma in animals?
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Minocycline has been shown to have an effect on glioma in animal models. In an orthotopic glioma implantation model, minocycline treatment reduced the expression of membrane type 1 matrix metalloprotease (MT1-MMP) in glioma-associated microglia and inhibited glioma growth . In a rat model of glioma, minocycline combined with temozolomide or radiation increased survival time compared to control groups . Minocycline treatment also inhibited tumor growth and prolonged survival time in a mouse model of glioma . Additionally, minocycline induced autophagic cell death in glioma cells and effectively inhibited tumor growth in a xenograft tumor model . These findings suggest that minocycline has potential as a therapeutic agent for the treatment of malignant gliomas in animals.
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| Papers (5) | Insight |
|---|---|
72 Citations | Yes, the paper mentions that minocycline effectively inhibited tumor growth and induced autophagy in a xenograft tumor model of C6 glioma cells in animals. |
39 Citations | Yes, the paper mentions that minocycline inhibits the growth of glioma in an intracranial mouse model and prolongs survival time in mice. |
1 Citations | Yes, the paper states that local delivery of minocycline in mice with intracranial 9L gliosarcoma resulted in 100% survival in contrast to untreated mice that died within 21 days. |
| The paper states that minocycline combined with either temozolomide or radiation increased survival in rats with intracranial gliosarcoma, suggesting that minocycline has an effect on glioma in animals. | |
93 Citations | Yes, the paper states that minocycline reduces glioma growth in an experimental mouse model. |
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