Search or ask a question

Is the Hexacosane compound a compound that has pharmacological effects?

Annona coriacea

Best insight from top research papers

Yes, the compound Hexacosane, also known as 9-hexacosene, has pharmacological effects. Research by David Kariuki et al. demonstrated that Hexacosane significantly inhibited chemical nociception and showed antinociceptive effects in pain behavior tests, indicating its analgesic properties . Additionally, a study by J. Huguet et al. revealed that Hexadecane (HDK), a similar compound, induced body weight loss and affected metabolic processes, suggesting pharmacological activity in terms of thermogenesis and metabolic balance . Furthermore, E. A. Kiseleva et al. found that a newly-synthesized compound related to Hexacosane showed high antinociceptive efficacy comparable to tramadol, indicating the pharmacological potential of similar compounds . Therefore, Hexacosane and related compounds exhibit pharmacological effects, particularly in pain management and metabolic regulation.

Answers from top 5 papers

PDF

Open Access

More filters

Papers (5)	Insight
Patent Hexacyclic compounds, pharmaceutical composition containing thereof and their using as antitumor agents, method for preparing hexacyclic compounds Такеси Мурата (Jp), Сатоси Ниизума (Jp), Нобуо Симма (Jp), Хитоми Суда (Jp), Масао Цуказаки (Jp) - Show less +4 more 25 Nov 2002	Not addressed in the paper.
Open access Analgesic and anti-inflammatory activities of 9-Hexacosene and Stigmasterol isolated from Mondia whytei David K. Kariuki, Titus I. Kanui, P M Mbugua, Charles Githua Githinji - Show less +3 more 01 Jan 2012 26 Citations	Yes, 9-Hexacosene, a compound isolated from Mondia whytei, exhibits significant analgesic effects, indicating its pharmacological potential, particularly in reducing pain behavior in formalin tests.
Open access•Journal Article•DOI Study Into Antinociceptive Activity of a New Molecule from the Class of Hexaazaizowurzitane E. A. Kiseleva, S. G. Krylova, Yu. V. Nesterova, Darya A. Kulagina, E. P. Zueva, N. I. Suslov, V. V. Eremina, O. V. Baibakova, S. V. Sysolyatin, Vadim V. Zhdanov - Show less +9 more 09 Apr 2023-Biomedicina	Not addressed in the paper.
Journal Article•DOI Alterations of energy metabolism induced by hexadecane in mice J. Huguet, J. Cartañà, Lluís Arola, Marià Alemany - Show less +3 more 01 Oct 1989-Archives of Physiology and Biochemistry 2 Citations	Not addressed in the paper.
Open access•Journal Article Pharmacological effects of the hexane and dichloromethane fractions from Annona coriacea Mart. (Annonaceae) leaves Orlando Vieira de Sousa, Glauciemar Del-Vecchio Vieira, José de Jesus Ribeiro Gomes de Pinho, Maria Silvana Alves, Maria Auxiliadora Coelho Kaplan - Show less +4 more 01 Jan 2011-Latin American Journal of Pharmacy 3 Citations	Not addressed in the paper.

My columns

Related Questions

What is the pharmacology of GHB?5 answersGamma-hydroxybutyrate (GHB) acts as a depressant on the central nervous system, binding to both GHB and GABAB receptors, primarily exerting its effects through GABAB agonist actions. GHB is known for its euphoric effects, sedative properties, and amnesic potential, contributing to its abuse potential and recreational use. The pharmacokinetics of GHB are complex, involving nonlinear absorption, metabolism, tissue uptake, and renal elimination processes, with GHB being a substrate for various transporters influencing its absorption and distribution in the body. Additionally, GHB is used as a performance-enhancing drug due to its impact on growth hormone release and sleep induction, although its recreational use extends beyond these effects to include enhancing various aspects of performance, mood, and energy levels.

What are the criticisms of hexaco?5 answersCritics of the HEXACO model have raised concerns regarding its distinctiveness from other personality models like the Big Six model, highlighting differences in trait measurements and predictive power. Additionally, research on the Dark Triad suggests that there may be more malevolent traits beyond the HEXACO factors, indicating potential limitations in capturing all dark personality traits. Furthermore, a study on trust behavior in adolescents found no significant evidence supporting the HEXACO dimensions as predictors of trust behavior, suggesting a potential lack of association between HEXACO traits and behaviors during adolescence. These criticisms underscore the need for further research to explore the limitations and boundaries of the HEXACO model in capturing the full spectrum of personality traits and behaviors.

Does Heptacosanolconsumption causes health issues?4 answersHeptacosanol, a type of alcohol compound, has shown various effects in different contexts. While heptadecanol, a similar compound, has been utilized for pain reduction and wound healing, heptanol, a gap junction inhibitor, has been linked to alterations in cardiac function and arrhythmias. Studies have demonstrated that heptanol can decrease electrical conduction velocity and induce arrhythmias in isolated hearts. However, heptacosanol specifically has not been directly studied in the provided contexts. It is crucial to note that different alcohols within this chemical group can have varying effects on health. Therefore, further research specifically focusing on heptacosanol is necessary to determine its potential health implications.

What are the pharmacological effects of corn silk?5 answersCorn silk has been found to have various pharmacological effects. It has been shown to have uric acid-lowering activity by decreasing xanthine oxidase (XOD) levels and increasing hypoxanthine-guanine phosphoribosyl transferase levels. Corn silk extracts have also demonstrated antioxidant properties, inhibiting lipid peroxidation in rat liver homogenate. Additionally, corn silk has been found to have pharmacological activities such as reducing gout, hypertension, diabetes, and photoaging. It contains compounds such as flavonoids, polysaccharides, phyto peptides, and polyphenols, which contribute to its various health benefits. Corn silk has been used traditionally as a diuretic, antilithiatic, and uricosuric, and has been used to treat cystitis, gout, kidney stones, and diabetes. It has also been claimed to have anti-fatigue and anti-depressant effects, as well as potential as an agent for reducing hyperglycemia. Corn silk extract has been found to suppress angiotensin converting enzyme, which is important in the management of hypertension.

Effects of hexane extracts on the lungs, kidney, cervix, ovaries and pancreas?5 answersHexane extracts have been found to have damaging effects on the lungs, liver, and kidneys. In a study by Yang et al., SD rats were exposed to hexane and showed significant pathological changes in these organs. Another study by Egeli et al. found that hexane exposure led to genotoxic and hematoxic effects, causing degeneration and lipid peroxidation in exposed groups. However, there is no specific mention of the effects of hexane extracts on the cervix, ovaries, or pancreas in the provided abstracts. It is important to note that these abstracts may not cover all the available research on the topic, so further investigation may be necessary to fully understand the effects of hexane extracts on these specific organs.

What is a hexene?2 answersHexene is a type of olefin, specifically an alkene, with the chemical formula C6H12. It is a hydrocarbon compound that contains six carbon atoms and has a double bond between two adjacent carbon atoms. Hexene can exist in different isomeric forms, such as 1-hexene, which is commonly used in the production of polymers and plastics. 1-hexene can be synthesized using various methods, including copolymerization with other alpha-olefins using specific catalysts. Another method involves trimerizing ethylene in the presence of a catalyst comprising a chromium compound, an alkyl metal compound, and an imide compound. Additionally, a preparation method for new hexene involves using an immobilized carbene metal catalyst and performing a disproportionation reaction between diisobutylene and ethylene. Hexene and its derivatives have unique properties and are widely used in various industrial applications.

See what other people are reading

What is common across seizure disorders and poisoning or toxic effects of drugs?

Seizures induced by poisoning or toxic effects of drugs share commonalities such as generalized tonic-clonic convulsions. Various substances like tramadol and tricyclic antidepressants can lead to drug-induced seizures, with tramadol being a significant contributor to morbidity and mortality. In cases of intentional isoniazid poisoning, seizures were observed, emphasizing the neurological impact of toxic substances. Additionally, intoxications involving antiepileptic drugs in children highlight the severity and complexity of multi-organ dysfunctions caused by poisoning. Recognizing the clinical features of toxicity early is crucial for targeted management, as seen in cases of opioid and paracetamol poisonings leading to significant intoxication and fatalities. These findings underscore the importance of prompt intervention and tailored treatment strategies for seizures induced by toxic agents.How plant extracts restores the cadmium affected carbohydrate content in liver of fish?

Plant extracts have shown promising effects in restoring carbohydrate content in the liver of fish affected by cadmium toxicity. Studies have demonstrated that plant extracts like Enhydra fluctuans and Lemna gibba L-extract can mitigate the toxic effects of cadmium exposure. These extracts have been found to reduce the accumulation of cadmium in fish tissues, leading to improvements in haematological parameters and amelioration of the toxic effects of cadmium. Additionally, the use of plant extracts has shown to increase the carbohydrate content in fish tissues, indicating a potential restoration of liver glycogen levels affected by cadmium exposure. The synergistic actions of compounds in these plant extracts may play a role in binding metallothionein and preventing the harmful effects of heavy metal accumulation in fish tissues.How opioids work?

Opioids primarily function by agonizing mu opioid receptors in various body systems, including the central nervous system, gastrointestinal tract, and immune cells. These agonistic actions lead to a range of effects, such as pain relief, sedation, constipation, and respiratory depression, which can be fatal. Opioids are classified based on their origin and structure, with examples like morphine, heroin, and tramadol. They bind to G-protein coupled opioid receptors, specifically mu, kappa, and delta receptors, causing therapeutic outcomes like analgesia, euphoria, and constipation, as well as adverse effects such as addiction and CNS depression. The pharmacokinetics of opioids vary, influencing factors like absorption, distribution, metabolism, and elimination from the body. Overall, opioids exert their effects by activating opioid receptors and modulating ion movement across cell membranes.How many branching points in percentage does the glycogen molecule contain?

The glycogen molecule contains branching points after every 4-8 residues, formed by 1→6-glycosidic bonds, which make up approximately 7% of the total number of bonds in the molecule. Additionally, glycogens typically consist of chains of α-(1 → 4)-linked D-glucose residues, with an average of about 12 glucose residues per chain. Around 40-50% of these residues can be removed by β-amylase, indicating longer exterior portions compared to the interior where branch points are closer together. The branching enzyme responsible for creating these α 1,6-glycosidic linkages is crucial for glycogen structure, with deficiencies leading to severe glycogen storage diseases. This enzyme's activity has been studied extensively, with experiments showing the impact of dietary interventions and supplementation on the degree of branching in mouse liver glycogen.What is known about the effect of skeletal muscle typology and recovery in exercise?

Skeletal muscle typology plays a crucial role in exercise recovery. Different fibre types, such as type I (slow, oxidative) and type II (fast, glycolytic), respond uniquely to exercise stimuli. Research suggests that both type I and type II fibres contribute similarly to regulating glycogen resynthesis under normal physiological conditions. Muscle typology influences the severity of fatigue and recovery time post-exercise, with fast-twitch fibres being more prone to fatigue and slower recovery compared to slow-twitch fibres. Additionally, a single bout of exercise activates satellite cells in both type I and type II muscle fibres, preceding an increase in satellite cell content during recovery. Understanding muscle typology's impact on recovery can aid in individualizing training programs to optimize performance and reduce the risk of fatigue-related issues.Why does copper exposure cause hatching impairment in fish?

Copper exposure causes hatching impairment in fish due to its inhibitory effects on key enzymes involved in hatching success. Exposure to copper disrupts the proteolytic activity of Zebrafish Hatching Enzyme 1, leading to delays or impairments in the hatching process. Additionally, copper exposure can affect the osmoregulatory system, electrolyte balance, and gene expression crucial for organ development in early life stages of fish, further contributing to hatching difficulties. Studies have shown that exposure to copper can result in morphological abnormalities, muscle fiber disorganization, and oxidative stress, all of which can significantly impact hatching success and decrease survival rates in polluted aquatic environments. Furthermore, copper exposure can induce thyroid disruption and developmental toxicity in fish embryos, exacerbating the hatching impairment.What are the advantages of Fixed-dose combination?

Fixed-dose combinations (FDCs) offer several advantages, including improved patient compliance, simplified dosage schedules, enhanced efficacy, cost-effectiveness, and streamlined packaging and shipment. They are particularly beneficial in chronic conditions where multiple disorders coexist, such as tuberculosis, cardiovascular diseases, diabetes, and HIV. FDCs can reduce the pill burden, provide predictable pharmacokinetics and pharmacodynamics, and minimize adverse events. Additionally, FDCs can optimize therapeutic efficacy and tolerability by combining multiple drug molecules at optimal doses and dosage forms. These combinations can lead to lower opioid consumption without sacrificing analgesic benefits and may offer synergistic effects, making them valuable additions to the treatment armamentarium.What type of glycogen are in fishes?

Fishes exhibit diverse glycogen characteristics based on species and tissues. Research indicates that teleost fish have higher glycogen content in erythrocytes compared to ray fishes, with thornback ray erythrocytes showing exceptional cold storage tolerance and economical glycogen expenditure. In hepatic tissues, seabass display glycogen synthesis primarily through indirect pathways, with negligible direct pathway conversion of dietary carbohydrates to glycogen. Furthermore, studies on Amazon fishes highlight a significant reliance on glycogen as a storage carbon and energy source in heart and muscle tissues, with unique glycogen storage patterns observed in different muscle types. Additionally, glycated parvalbumins in fish impact allergenicity and cross-reactivity, with glycosylation influencing immunoglobulin E binding and cytokine expression, thereby modulating sensitization and cross-reactivity.Does elevated glucose impact the brain's white matter?

Elevated glucose levels have a significant impact on the brain's white matter. Studies have shown that in individuals with small vessel disease, there is a relative elevation in glycolysis in nonlesional white matter, indicating a marker of pathology associated with the disease. Additionally, research on individuals with type 2 diabetes revealed that high glucose concentrations, particularly 2-hour serum glucose levels, are independently associated with increased white matter hyperintensities, which are linked to stroke risk and cognitive decline. Furthermore, the impact of blood glucose fluctuations in Type 1 diabetes on white matter structure is being explored using diffusion tensor imaging, highlighting the importance of understanding the cumulative effects of hyperglycemia on the central nervous system. These findings underscore the detrimental effects of elevated glucose on white matter integrity in the brain.What are the most common non-opioid medications used as alternatives to opioids in pain management?

Non-opioid medications commonly used as alternatives to opioids in pain management include nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen, antidepressants, anticonvulsants, muscle relaxants, and corticosteroids. These medications are effective for managing various types of pain such as headaches, osteoarthritis, neuropathy, and bone pain. Additionally, the American College of Rheumatology recommends the use of topical NSAIDs and oral NSAIDs for arthritis pain, while the American Headache Society suggests NSAIDs and combination medications like acetaminophen, aspirin, and caffeine for migraine pain. Furthermore, the American Dental Association supports NSAIDs and NSAID/acetaminophen combinations as safe and effective first-line options for managing acute dental pain. These non-opioid alternatives offer effective pain relief with lower risks of abuse and addiction compared to opioids.What is the respiratory response to hypoxia in fetuses in a transferred pregnancy?

The respiratory response to hypoxia in fetuses in a transferred pregnancy involves complex adaptations. Fetal exposure to alcohol during gestation can compromise respiratory chemoreflex in offspring, potentially putting neonates at risk. Hypoxemia in the fetus induces various physiological responses, including changes in blood glucose and lactate concentrations to ensure survival in sub-optimal intrauterine conditions. The fetus, existing in a hypoxemic state due to the placenta, responds to hypoxic insults crucially, with advancements in understanding fetal physiology aiding in clinical care. While traditional respiratory physiology attributes the increased ventilatory response to hypoxia to carotid-body chemoreceptor discharge, a new model proposing direct stimulation of solitary-tract neurons by nitric oxide-derived molecules is debated. These findings collectively highlight the intricate mechanisms governing the respiratory response to hypoxia in fetuses during transferred pregnancies.