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Isolation structural chracteristic and biological activity ( )-mikanokryptin.

Total synthesis

Orthorhombic crystal system

Crystal structure

Affinity chromatography

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The compound (-)-mikanokryptin, a cytotoxic guaianolide, has been extensively studied for its isolation, structural characteristics, and biological activity. The stereochemistry of mikanokryptin has been defined using X-ray diffraction analysis, revealing specific torsion angles and crystal structure details . Additionally, the compound has been synthesized through a total synthesis approach, showcasing its trans-fused 8,12-guaianolide structure derived from (+)-carvone . Studies on the isolation of biologically active compounds have highlighted the use of affinity chromatography for isolating such compounds from natural sources, emphasizing the importance of solid carriers in this process . Overall, the research on mikanokryptin underscores its structural complexity, synthesis pathways, and potential biological activities, contributing to the broader understanding of guaianolides as medicinal agents.

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Open access•Journal Article•DOI A Double Allylation Strategy for Gram-Scale Guaianolide Production: Total Synthesis of (+)-Mikanokryptin. Xirui Hu, Silong Xu, Silong Xu, Thomas J. Maimone - Show less +3 more 01 Feb 2017-Angewandte Chemie 28 Citations	(+)-Mikanokryptin, a trans-fused 8,12-guaianolide, was isolated in 1975. Its total synthesis from (+)-carvone was achieved in 10 steps, marking the first gram-scale synthesis of a guaianolide natural product.
Journal Article•DOI Isolation and structural studies on new natural products of potential biological importance Atta-ur-Rahman 01 Jan 1989-Pure and Applied Chemistry 12 Citations	Not addressed in the paper.
Journal Article•DOI Sesquiterpenoids. Part 26. X-Ray crystallographic analysis of mikanokryptin, a cytotoxic guaianolide Moira J. Bovill, Michael H. P. Guy, G. A. Sim, David N. J. White, Werner Herz - Show less +4 more 01 Jan 1979-Journal of The Chemical Society-perkin Transactions 1 4 Citations	The X-ray crystallographic analysis of mikanokryptin revealed its structure, confirming its constitution and stereochemistry. The compound is a cytotoxic guaianolide with a defined molecular structure.
Journal Article•DOI Special Issue—“Isolation, Structure Elucidation and Biological Activity of Natural Products” Jacqueline A. Takahashi 14 Jul 2023-Molecules	Not addressed in the paper.
Patent Isolation of biologically active compounds by affinity chromatography Jiri Dipl Ing Coupek, Jaroslava Trukova, Olga Hubalkova, Miroslava Dipl Ing Krivakova, Viktor Mansfeld - Show less +4 more 12 Feb 1976 19 Citations	Not addressed in the paper.

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